Urinary excretion of exogenous glycerol administration at rest

Urinary excretion of exogenous glycerol administration at rest / Karsten Koehler, Hans Braun, Markus de Marees, Hans Geyer, Mario Thevis, Joachim Mester, Wilhelm Schaenzer. - (Drug Testing and Analysis 3 (2011) 11-12 (November-December); p. 877-882). - Special Issue: 29th Cologne Workshop: Advances in Sports Drug Testing

  • PMID: 22012747
  • DOI: 10.1002/dta.355


Abstract

Since 2010, glycerol has been ruled a masking agent by the World Anti-Doping Agency and consequently its administration is prohibited in sports. A detection method is available but little is known about the urinary excretion following administration. Fourteen well-trained cyclists (27.0 ± 5.4 years; VO(2max): 63.9 ± 8.5 ml/kg/min) were administered glycerol (1 g/kg body mass + 25 ml water/kg body mass) and placebo (25 ml water/kg) in a cross-over study. Blood and urine samples were collected before administration and after 2.5, 4, and 6.5 h. Urine samples were further collected up to 24 h post-administration. Following glycerol administration, urinary glycerol increased from 10.9 ± 15.5 to 50581 ± 23821 µg/ml within 2.5 h. In the placebo group, urinary glycerol did not exceed 26.8 ± 31.3 µg/ml. Urinary concentrations in the glycerol group were significantly higher than in the placebo group for 16.9 ± 1.0 h. In comparison to placebo, glycerol caused a larger increase in body weight (0.69 ± 0.42 vs. 0.27 ± 0.44 kg; p < 0.05) and a reduced urine output (972 ± 379 vs. 1271 ± 387 ml; p < 0.05). Reductions in haemoglobin and haematocrit were significantly greater after glycerol (-0.60 ± 0.28 g/dl; -1.7 ± 0.7%) than after placebo administration (-0.29 ± 0.39 g/dl; -0.9 ± 1.1%). The study shows that glycerol administration was detectable in urine for several hours. Even though there were significant reductions in haemoglobin and haematocrit after 2.5 h, the plasma expansion by glycerol appeared rather marginal in comparison to placebo.

Original document

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Science
Research / Study
Date
19 October 2011
People
Braun, Hans
Geyer, Hans
Koehler, Karsten
Marees, M. de
Mester, J.
Schänzer, Wilhelm
Thevis, Mario
Country
Germany
Language
English
Other organisations
Deutsche Sporthochschule Köln (DSHS) - German Sport University Cologne
Analytical aspects
Half-life / excretion time of substance
Doping classes
S5. Diuretics and Other Masking Agents
Substances
Glycerol
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Abstract
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Date generated
23 April 2012
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25 January 2022
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