Current strategic approaches for the detection of blood doping practices

Current strategic approaches for the detection of blood doping practices / Jordi Segura, Rosa Ventura, José A. Pascual. - (Forensic Science International (2011) 213 (10 December) ; p. 42-48)

  • PMID: 21889274
  • DOI: 10.1016/j.forsciint.2011.07.029


Abstract:

Aerobic sport performance may be strongly influenced by the number of red blood cells available for transport and delivery of oxygen from lungs to muscles. Often, athletes search for an acute increase in red blood cells by means of blood transfusions. This paper reviews the possibilities for detecting such prohibited practice. Flow cytometry methods are able to detect a double population of red blood cell membrane surface antigens, thus revealing an allogeneic transfusion. Other ingenious approaches for total hemoglobin mass measurements or to test for the metabolites of blood bag plasticizers in urine are new trends for facing the detection of autologous transfusions. Steady increase of red blood cell number may be obtained also by erythropoietic stimulant agents such as erythropoietin, analogs and mimetics. The challenge of detecting those substances has stimulated the development of indirect markers of altered erythropoiesis, leading to the consequent development of the hematological blood passport approach, which is gaining legal acceptance.

Original document

Parameters

Science
Review
Date
1 September 2011
People
Pascual, José Antonio
Segura, Jordi
Ventura, Rosa
Country
Spain
Language
English
Other organisations
Universitat Pompeu Fabra (UPF) - Pompeu Fabra University
Laboratories
Barcelona, Spain: Antidoping Laboratory Fundació Institut Mar D'Investigacions Mèdiques (IMIM)
Analytical aspects
Testing method development
Doping classes
M1. Manipulation Of Blood And Blood Components
S2. Peptide Hormones, Growth Factors
Substances
Erythropoietin (EPO)
Medical terms
Blood doping
Intravenous infusions
Document category
Abstract
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Pdf file
Date generated
28 February 2012
Date of last modification
6 January 2022
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  • Analytical aspects
  • Doping classes
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  • Various
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