Time Trial Performance Is Sensitive to Low-Volume Autologous Blood Transfusion

Time Trial Performance Is Sensitive to Low-Volume Autologous Blood Transfusion / Jacob Bejder, Andreas Breenfeldt Andersen, Sara Amalie Solheim, Mikkel Gybel-Brask, Niels H. Secher, Pär I. Johansson, Nikolai Baastrup Nordsborg. - (Medicine and science in sports and exercise (2018) 6 november).
- PMID: 30407276.
- DOI: 10.1249/MSS.0000000000001837

This study tested the hypothesis that autologous blood transfusion (ABT) of ~50% of the red blood cells (RBCs) from a standard 450 ml phlebotomy would increase mean power in a cycling time trial. Additionally, the study investigated whether further ABT of RBCs obtained from another 450 ml phlebotomy would increase repeated cycling sprint ability.

In a randomized, double-blind, placebo-controlled crossover design (3-month wash-out), nine highly trained male subjects donated two 450 ml blood bags each (BT-trial) or were sham phlebotomized (PLA-trial). Four weeks later, a 650 kcal time trial (n=7) was performed three days before and 2 h after receiving either ~50% (135 ml) of the RBCs or a sham transfusion. On the following day, transfusion of RBCs (235 ml) from the second donation or sham transfusion was completed. A 4×30 s all-out cycling sprint interspersed by 4 min of recovery was performed six days before and three days after the second ABT (n=9).

The mean power was increased in time trials from before to after transfusion (P<0.05) in BT (213±35 vs. 223±38 W; mean±SD) but not in PLA (223±42 vs. 224±46 W). In contrast, the mean power output across the four 30 s sprint bouts remained similar in BT (639±35 vs. 644±26 W) and PLA (638±43 vs. 639±25 W).

ABT of only ~135 ml of RBCs is sufficient to increase mean power in a 650 kcal cycling time trial by ~5% in highly trained men. In contrast, a combined high-volume transfusion of ~135 and ~235 ml of RBCs does not alter 4×30 s all-out cycling performance interspersed with 4 min of recovery.


Research / Study
6 November 2018
Andersen, Andreas Breenfeldt
Bejder, Jacob
Gybel-Brask, Mikkel
Johansson, Pär I.
Nordsborg, Nikolai Baastrup
Secher, Niels H.
Solheim, Sara Amalie
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Københavns Universitet - University of Copenhagen (UCPH)
Københavns Universitetshospital - Copenhagen University Hospital
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M1. Manipulation Of Blood And Blood Components
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Blood doping
Intravenous infusions
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Date generated
15 January 2019
Date of last modification
19 February 2019
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