Annual banned-substance review: analytical approaches in human sports drug testing / Mario Thevis, Tiia Kuuranne, Hans Geyer. - (Drug testing and analysis 12 (2020) 1 (January); p. 7-26)
- PMID: 31724288
- DOI: 10.1002/dta.2735
Contents:
- Introduction
- Anabolic Agents
- Anabolic-androgenic steroids
- Initial testing procedures: Comprehensive screening, metabolism studies
- Steroid profiling in urine and serum
- Confirmatory testing procedures – IRMS
- Other anabolic agents
- Peptide Hormones, Growth Factors, Related Substances, and Mimetics
- Erythropoietin-receptor agonists and transforming growth factor-beta (TGR- β) inhibitors)
- Hypoxia-inducible factor (HIF) activating agents
- Growth hormone, its fragments and releasing factors, chorionic gonadotrophin and luteinizing hormone (LH)
- β2‐Agonists
- Hormone and Metabolic Modulators
- Diuretics and other Masking Agents, Stimulants, Narcotics, beta-blockers
- Manipulation of blood and blood components
- Gene Doping
- Conclusion
Abstract
Within the complex construct of today's anti-doping work, continuously updated routine doping controls as well as advancements in sampling and analysis have been of particular relevance and importance. New analytes of existing classes of prohibited substances are frequently included into sports drug testing assays, analytical approaches are optimized to allow for better sensitivities, selectivity, and/or faster turnaround times, and research dedicated to addressing analytical issues concerning scenarios of both (potentially) inadvertent doping and new emerging doping agents is constantly conducted. By way of reviewing and summarizing, this annual banned-substance review evaluates literature published between October 2018 and September 2019 offering an in-depth evaluation of developments in these arenas and their potential application to substances reported in WADA's 2019 Prohibited List.
