Inter-individual Variation of the Urinary Steroid Profiles in Swedish and Norwegian Athletes

Inter-individual Variation of the Urinary Steroid Profiles in Swedish and Norwegian Athletes / Jenny Mullen, Lasse Vestli Baekken, Timo Törmäkangas, Lena Ekström, Magnus Ericsson, Ingunn R. Hullstein, Jenny J. Schulze. - (Drug Testing and Analysis (2020) 12 February; p. 1-18).
- PMID: 32052600.
- DOI: 10.1002/dta.2778
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Abstract

The steroidal module of the Athlete Biological Passport (ABP) aims to detect doping with endogenous steroids, e.g. testosterone (T), by longitudinally monitoring several biomarkers. These biomarkers are ratios combined into urinary concentrations of testosterone and metabolically related steroids. However, it is evident after 5 years of monitoring steroid passports that there are large variations in the steroid ratios complicating its interpretation. In this study, we used over 11000 urinary steroid profiles from Swedish and Norwegian athletes to determine both the inter- and intra-individual variations of all steroids and ratios in the steroidal passport. Furthermore, we investigated if the inter-individual variations could be associated with factors such as gender, type of sport, age, time of day, time of year, and if the urine was collected in or out of competition. We show that there are factors reported in today's doping tests that significantly affect the steroid profiles. The factors with the largest influence on the steroid profile were the type of sport classification that the athlete belonged to as well as whether the urine was collected in or out of competition. There were also significant differences based on what time of day and time of year the urine sample was collected. Whether these significant changes are relevant when longitudinally monitoring athletes in the steroidal module of the ABP should be evaluated further.

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Science
Study
Date:
12 February 2020
People
Ekström, Lena
Ericsson, Magnus
Hullstein, Ingunn R.
Mullen, Jenny
Schulze, Jenny J.
Törmäkangas, Timo
Vestli Baekken, Lasse
Country
Finland
France
Norway
Sweden
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English
ADRV
Adverse Analytical Finding / presence
Other organisations
Antidoping Norge - Anti-Doping Norway
Jyväskylän yliopisto - University of Jyväskylä
Riksidrottsförbundet (RF) - Swedish Sports Confederation
Laboratories
Oslo, Norway: Norwegian Doping Control Laboratory
Paris, France: Agence Française de Lutte contre le Dopage (AFLD)
Stockholm, Sweden: Doping Control Laboratory
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Athlete Biological Passport (ABP)
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