Tramadol Does Not Improve Performance or Impair Motor Function in Trained Cyclists

Tramadol Does Not Improve Performance or Impair Motor Function in Trained Cyclists / Jacob Bejder, Andreas Breenfeldt Andersen, Thomas Christian Bonne, Jacob Feder Piil, Linn Camilla Hauan Hagen, Yvette Dehnes, Kasper Hvid Eibye, Lars Nybo, Nikolai Baastrup Nordsborg. - (Medicine & Science in Sports & Exercise (2019, 27 November)).
- PMID: 31809408.
- DOI: 10.1249/MSS.0000000000002217


Abstract

Purpose: To investigate the hypothesis that a therapeutic oral dose of Tramadol improves cycling time trial performance and compromises motor-cognitive performance in highly trained cyclists.

Methods: Following two familiarization trials, 16 highly trained cyclists completed a preloaded time trial (1 hour at 60 % of peak power followed by a 15 km time trial) after ingestion of 100 mg Tramadol or placebo in a double-blind placebo-controlled counterbalanced cross-over design separated by at least 4 days wash-out. Visuo-motor tracking and math tasks were completed during the preload (n=10) to evaluate effects on cognition and fine motor performance.

Results: Time trial mean power output (298±42 W vs. 294±44 W) and performance (1474±77 s vs. 1483±85 s) were similar with Tramadol and placebo treatment, respectively. In addition, there were no differences in perceived exertion, reported pain, blood pH, lactate or HCO3 concentrations across trials. Heart rate was higher (P<0.001) during the Tramadol time trial (171±8 bpm) compared to placebo (167±9 bpm). None of the combined motor-cognitive tasks were impaired by Tramadol ingestion, in fact fine motor performance was slightly improved (P<0.05) in the Tramadol trial compared to placebo.In highly trained cyclists, ingestion of 100 mg Tramadol does not improve performance in a 15 km cycling time trial that was completed after a one hour preload at 60 % peak power. Additionally, a therapeutic dose of Tramadol does not compromise complex motor-cognitive or simple fine motor performances.

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Science
Research / Study
Date
27 November 2019
People
Andersen, Andreas Breenfeldt
Bejder, Jacob
Bonne, Thomas Christian
Dehnes, Yvette
Eibye, Kasper Hvid
Hagen, Linn Camilla Hauan
Nordsborg, Nikolai Baastrup
Nybo, Lars
Piil, Jacob Feder
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Denmark
Norway
Language
English
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Cycling (UCI) - International Cycling Union
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Københavns Universitet - University of Copenhagen (UCPH)
Oslo universitetssykehus HF - Oslo University Hospital
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S7. Narcotics
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Tramadol
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30 March 2020
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