Selective Androgen Receptor Modulators (SARMs) as Pharmacological Treatment for Muscle Wasting in Ongoing Clinical Trials

Selective Androgen Receptor Modulators (SARMs) as Pharmacological Treatment for Muscle Wasting in Ongoing Clinical Trials / Guilherme Wesley Peixoto Da Fonseca, Elke Dworatzek, Nicole Ebner, Stephan Von Haehling. - (Expert Opinion on Investigational Drugs (2020) 18 June; p. 1-11)

  • PMID: 32476495
  • DOI: 10.1080/13543784.2020.1777275


Introduction: Skeletal muscle wasting is a frequent clinical problem encountered in patients with chronic diseases. Increased levels of inflammatory markers play a role in the imbalance between muscle protein synthesis and degradation. Although testosterone has long been proposed as a treatment for patients with muscle wasting, undesirable side effects have raised concerns about prostatic hypertrophy in men as well as virilization in women. Selective androgen receptor modulators (SARMs) have demonstrated similar results like testosterone at improving lean body mass (LBM) with less side effects on androgen-dependent tissue.

Areas covered: This review outlines the ongoing clinical development in the field of SARMs and their effectiveness in improving body composition and physical function. The included articles were collected at and analyzed integrally.

Expert opinion: There is an unmet clinical need for safe and effective anabolic compounds such as SARMs. Despite the effect on LBM shown by SARMs in phase II clinical trials, results on improved physical function and muscle strength are still lacking and long-term outcomes have to be assessed in these patients. Moreover, there is a need to determine the effect of resistance exercise training and protein intake associated with SARMs in the treatment of patients with muscle wasting.


18 June 2020
Dworatzek, Elke
Ebner, Nicole
Peixoto Da Fonseca, Guilherme Wesley
Von Haehling, Stephan
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Charité Universitätsmedizin Berlin - Charité Berlin University of Medicine
Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK) - German Center for Cardiovascular Research
Freie Universität Berlin (FU Berlin) - Free University of Berlin
Georg-August-Universität Göttingen - Georg August University of Göttingen
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo - University of São Paulo Faculty of Medicine Clinics Hospital
Max Delbrück Center for Molecular Medicine in the Helmholtz Association
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S1. Anabolic Agents
Selective androgen receptor modulators (SARMs)
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Legitimate Medical Treatment
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Date generated
16 June 2020
Date of last modification
5 August 2020
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