Androgen regulation of satellite cell function

Androgen regulation of satellite cell function / Yue Chen, Jeffrey D. Zajac, Helen E. MacLean. - (Journal of Endocrinology 186 (2005) 1 (July); p. 21–31)

  • PMID: 16002532
  • DOI: 10.1677/joe.1.05976


Abstract

Androgen treatment can enhance the size and strength of muscle. However, the mechanisms of androgen action in skeletal muscle are poorly understood. This review discusses potential mechanisms by which androgens regulate satellite cell activation and function. Studies have demonstrated that androgen administration increases satellite cell numbers in animals and humans in a dose-dependent manner. Moreover, androgens increase androgen receptor levels in satellite cells. In vitro, the results are contradictory as to whether androgens regulate satellite cell proliferation or differentiation. IGF-I is one major target of androgen action in satellite cells. In addition, the possibility of non-genomic actions of androgens on satellite cells is discussed. In summary, this review focuses on exploring potential mechanisms through which androgens regulate satellite cells, by analyzing developments from research in this area.

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Science
Review
Date
5 May 2005
People
Chen, Yue
Maclean, Helen E.
Zajac, Jeffrey D.
Country
Australia
Language
English
Other organisations
University of Melbourne
Doping classes
S1. Anabolic Agents
S2. Peptide Hormones, Growth Factors
Substances
Insulin-like Growth Factor-1 (IGF-1)
Medical terms
Legitimate Medical Treatment
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Scientific article
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Date generated
16 June 2020
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5 August 2020
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