Short-term rhGH increases PIIINP, a biomarker of endothelial dysfunction

Short-term rhGH increases PIIINP, a biomarker of endothelial dysfunction / Michael R. Graham, Yaodong Gu, P.J. Evans, S.M. Cooper, Bruce Davies, Julien S. Baker. - (International Journal of Advanced Engineering Research and Science 4 (2017) 7 (July); p. 164-173)

  • DOI: 10.22161/ijaers.4.7.26


Objectives: In arterial hypertension, amino-terminal pIII procollagen ropeptide of type (PIIINP) is elevated in arterial aneurysm tissue and associated with a poor prognosis following acute myocardial infarction (MI). Recombinant human growth hormone (rhGH) administration attenuates endothelial dysfunction but increases PIIINP. This study was conducted to establish if short-term rhGH administration affects PIIINP, endothelial function and selected cardiovascular disease (CVD) risk factors, in healthy males.

Design: Method: Male subjects (n=48) were randomly assigned into two groups: (1): control group (C) n=24, mean ± SD, age 32 ± 11 years; height 1.8 ± 0.06 metres; (2): rhGH administration group (rhGH) n=24, mean ± SD, age 32 ± 9 years; height 1.8 ± 0.07 metres. Blood pressure (BP), heart rate (HR), arterial pulse wave velocity (APWV), and biochemical indices were investigated.

Results: PIIINP (0.28±0.1 vs. 0.42±0.2, U/ml); Insulin like growth factor-I (159±54 vs. 323±93, ng.mL-1); resting HR (72±14 vs. 78±11, b.p.m.) and rate pressure product (RPP) (90±18 vs. 97±14, bpm x mm.Hg x 10-2) all significantly increased (P<0.05). Total cholesterol (4.7±0.9 vs. 4.4±0.7, mmol.L-1); high sensitivity C-reactive protein (1.77±2.1 vs. 1.29±1.6, mg.L-1); serum homocysteine (13.2±4.0 vs. 11.7±3.1, μmol.L-1) and APWV (9.97±1.38 vs. 9.18±1.6, m.s-1) all significantly decreased (P<0.05).

Conclusion: Paradoxically, there was an improvement in CVD inflammatory markers and APWV; but PIIINP and resting RPP increased. Elevated PIIINP may have a confounding adverse effect on the endothelium, but may also provide clinical prognostic information in monitoring arterial hypertension, left ventricular function in the sub-acute phase following MI and endothelial function in aortic aneurysms. 

Original document


Research / Study
1 July 2017
Baker, Julien S.
Cooper, Stephen-Mark
Davies, Bruce
Evans, P.J.
Graham, Michael R.
Gu, Yaodong
United Kingdom
Other organisations
Cardiff Metropolitan University
Ningbo University (NBU)
Royal Gwent Hospital
University of South Wales
University of the West of Scotland
Doping classes
S2. Peptide Hormones, Growth Factors
Growth hormone (GH)
Medical terms
Health effects
High Blood Pressure (Hypertension)
Document category
Scientific article
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Pdf file
Date generated
21 July 2020
Date of last modification
16 September 2020
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