In Vitro and in vivo metabolism of RAD140, a novel non-steroidal SARM / Tim Sobolevsky, M. Dikunets, Grigory Rodchenkov. - . - (Recent advances in doping analysis (21) : Proceedings of the Manfred-Donike-Workshop ; 31th Cologne Workshop on Dope Analysis ; 24th February to 1st March 2013; p. 121-124)
- ISBN 978-3-86884-039-1
The selective androgen receptor modulator RAD140 has been recently developed as a potent and orally bioavailable drugintended for the treatment of muscle wasting condition related to various malignant deceases.The experiments on an invitro and in vivo metabolism of RAD140 (synthesized in-house) were conducted, which showed that this compound is metabolically stable. Using liquid chromatography – electrospray mass spectrometry in negative ionization mode,unchanged RAD140 can be detected in urine at least 8 days after administration of a single oral dose of 10 mg.