Rifampicin for Treatment of Cholestatic Pruritus Caused by Drug-Induced Acute Liver Injury as Assessed by the RUCAM Classification

Rifampicin for Treatment of Cholestatic Pruritus Caused by Drug-Induced Acute Liver Injury as Assessed by the RUCAM Classification / Ali R. Ahmadi, Maria Chicco, Marcel van den Berge. - (Case Reports in Hepatology (2020) 872804 (8 August); p. 1-5)

  • PMID: 32832174
  • PMCID: PMC7429806
  • DOI: 10.1155/2020/8872804

Abstract

A male bodybuilder of 39 years of age developed severe pruritus, nausea, and jaundice after injecting anabolic steroids purchased on the black market. The patient had no history of liver disease and no risk factors for viral hepatitis. Extensive laboratory testing, radiographic imaging, and liver biopsy excluded a majority of potential pathologies. The patient was diagnosed with drug-induced acute liver injury and secondary acute renal failure most likely caused by testosterone purchased on the black market. The pruritus caused insomnia and significant psychological distress. Treatment was initiated with cholestyramine and naltrexone for one week with no effect on the pruritus. Subsequently, all medications were stopped, and rifampicin was started. Pruritus resolved after starting rifampicin, and liver and kidney function improved rapidly and normalized within 5 months.

Original document

Parameters

Science
Case report
Date
7 August 2020
Country
Netherlands
United Kingdom
Language
English
Other organisations
Admiraal de Ruyter Ziekenhuis - Admiraal de Ruyter Hospital
Erasmus MC - Erasmus University Medical Center
Wexham Park Hospital
Doping classes
S1. Anabolic Agents
Substances
Testosterone
Medical terms
Health effects
Various
Gym/fitness environment
Document category
Scientific article
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Pdf file
Date generated
2 September 2020
Date of last modification
13 September 2020
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  • Legal Source
  • Education
  • Science
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  • ADRV
  • Legal Terms
  • Sport/IFs
  • Other organisations
  • Laboratories
  • Analytical aspects
  • Doping classes
  • Substances
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  • Various
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