Clomiphene Stimulation Test in Men Abusing Anabolic-Androgenic Steroids for Long Time

Clomiphene Stimulation Test in Men Abusing Anabolic-Androgenic Steroids for Long Time / M. Medras, Pawel Zóźków, L. Terpilowski, E. Zagocka. - (Journal of Steroids & Hormonal Science 5 (2014) 2 (30 April); p. 1-4)

  • DOI: 10.4172/2157-7536.1000129

Abstract:

Objective: Androgenic-anabolic steroids (AAS) are commonly used by athletes and recreational athletes. In some cases they induce persistent anabolic steroid-induced hypogonadism (ASIH).

Design: In an observational study we assessed the function of the pituitary-gonadal axis in a series of men with suspected ASIH.

Methods: Clomiphene stimulation test (CST) was performed in 13 hypogonadal adult men with previous, prolonged exposure to AAS. We evaluated the response of luteinizing hormone (LH), follicle-stimulating hormone (FSH) and total testosterone (T) to 50 mg of clomiphene daily administered for a week. Mean concentrations of hormones before and after clomiphene administration were respectively (mean ± SD): 3 ± 1.2 and 8.3 ± 2 mIU/ml for LH; 3 ± 1.1 and 10 ± 14.6 mIU/ml for FSH; and 2.3 ± 0.6 and 7.2 ± 1.7 ng/ml for T (p<0.001).

Conclusions: Men with ASIH, after a long-time withdrawal of AAS, present an intact reaction of gonadotropins and testosterone to clomiphene stimulation.

Original document

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Study
Date
30 April 2014
People
Medras, M.
Terpilowski, L.
Zagocka, E.
Zóźków, Pawel
Country
Poland
Language
English
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Akademia Wychowania Fizycznego we Wrocławiu - Wrocław University School of Physical Education
Uniwersytet Medyczny we Wrocławiu - Wrocław Medical University
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S4. Hormone And Metabolic Modulators
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Clomifene
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Hypogonadism
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7 September 2020
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11 September 2020
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