Impact of dehydroepianrosterone (DHEA) supplementation on serum levels of insulin-like growth factor 1 (IGF-1)

Impact of dehydroepianrosterone (DHEA) supplementation on serum levels of insulin-like growth factor 1 (IGF-1) : A dose-response meta-analysis of randomized controlled trials / Min Xie, Yanfa Zhong, Qing Xue, Meirong Wu, Xiaoxian Deng, Heitor O. Santos, Shing Cheng Tan, Hamed Kord-Varkaneh, Peng Jiao. - (Experimental Gerontology 136 (2020) 110949 (15 July);

  • PMID: 32304719
  • DOI: 10.1016/j.exger.2020.110949

Abstract

Background and aim: Inconsistencies exist with regard to the influence of dehydroepiandrosterone (DHEA) supplementation on insulin-like growth factor 1 (IGF-1) levels. The inconsistencies could be attributed to several factors, such as dosage, gender, and duration of intervention, among others. To address these inconsistencies, we conducted a systematic review and meta-analysis to combine findings from randomized controlled trials (RCTs) on this topic.

Methods: Electronic databases (Scopus, PubMed/Medline, Web of Science, Embase and Google Scholar) were searched for relevant literature published up to February 2020.

Results: Twenty-four qualified trials were included in this meta-analysis. It was found that serum IGF-1 levels were significantly increased in the DHEA group compared to the control (weighted mean differences (WMD): 16.36 ng/ml, 95% CI: 8.99, 23.74; p = .000). Subgroup analysis revealed that a statistically significant increase in serum IGF-1 levels was found only in women (WMD: 23.30 ng/ml, 95% CI: 13.75, 32.87); in participants who supplemented 50 mg/d DHEA (WMD: 15.75 ng/ml, 95% CI: 7.61, 23.89); in participants undergoing DHEA intervention for >12 weeks (WMD: 17.2 ng/ml, 95% CI: 8.02, 26.22); in participants without an underlying comorbidity (WMD: 19.11 ng/ml, 95% CI: 10.69, 27.53); and in participants over the age of 60 years (WMD: 19.79 ng/ml, 95% CI: 9.86, 29.72).

Conclusion: DHEA supplementation may increase serum IGF-I levels especially in women and older subjects. However, further studies are warranted before DHEA can be recommended for clinical use.

Parameters

Science
Review
Date
15 April 2020
People
Deng, Xiaoxian
Jiao, Peng
Kord-Varkaneh, Hamed
Santos, Heitor O.
Tan, Shing Cheng
Wu, Meirong
Xie, Min
Xue, Qing
Zhong, Yanfa
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Brazil
China
Iran, Islamic Republic of
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English
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Central South University (CSU), China
Dezhou Hospital of Traditional Chinese Medicine
Shahid Beheshti University of Medical Sciences
Universidade Federal de Uberlândia (UFU) - Federal University of Uberlândia
Universiti Kebangsaan Malaysia (UKM) - National University of Malaysia
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S1. Anabolic Agents
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Insulin-like Growth Factor-1 (IGF-1)
Prasterone (dehydroepiandrosterone, DHEA, 3β-hydroxyandrost-5-en-17-one)
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Health effects
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22 October 2020
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27 October 2020
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