Undeclared furosemide in food supplements

Undeclared furosemide in food supplements / Stanislava Ivanova, Kalin Ivanov. - (Biomedical Research 30 (2019) 5; p. 733-737)

  • Doi: 10.35841/biomedicalresearch.30-19-314

Abstract

Recent studies claim that dietary supplements could contain pharmaco-active ingredients or undeclared drug substances with a potential health risk. Most often these products are contaminated with anabolic steroids, ephedrine, sibutramine, diuretics and others. The intake of a contaminated dietary supplement could lead to serious health consequences (the pharmacological effect of the substances, side effects, drug interactions and many others) or other negative consequences like failure of a doping test (for professional athletes). We have performed HPLC screening for furosemide. Measurements were performed at 228 nm at a flow rate 0,8 ml/min. The mobile phase was composed of methanol and water in a ratio 80: 20 (v/v). The pH of the mobile phase was 3,3 adjusted with Phosphorous acid. Chromatographic column - Microsorb-MV 100-5 C18 150 × 4.6 mm. We have analysed 30 food supplements in the category”prostate health”. We have found undeclared furosemide in 10% of the samples.

Original document

Parameters

Science
Study
Date
23 July 2019
People
Ivanov, Kalin
Ivanova, Stanislava
Country
Bulgaria
Language
English
Other organisations
Медицински университет в Пловдив - Plovdiv Medical University
Doping classes
S5. Diuretics and Other Masking Agents
Substances
Furosemide
Medical terms
Health effects
Various
Contamination
Supplements
Document category
Scientific article
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Pdf file
Date generated
2 December 2020
Date of last modification
5 December 2020
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  • Legal Source
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  • ADRV
  • Legal Terms
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  • Analytical aspects
  • Doping classes
  • Substances
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  • Various
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