Death after misuse of anabolic substances (clenbuterol, stanozolol and metandienone)

Death after misuse of anabolic substances (clenbuterol, stanozolol and metandienone) / Sabrina Lehmann, Andreas Thomas, Karl-Heinz Schiwy-Bochat, Hans Geyer, Mario Thevis, Frank Glenewinkel, Markus Alexander Rothschild, Hilke Andresen-Streichert, Martin Juebner. - (Forensic Science International 303 (2019) 109925 (October))

  • PMID: 31499423
  • DOI: 10.1016/j.forsciint.2019.109925


Abstract

A 34-year old male was found breathless and panting at home by his girlfriend three hours after a gym workout. Minutes later, he collapsed and died. Autopsy, histological and chemical analyses were conducted. The examination of the heart showed left ventricular hypertrophy, while the right coronary artery showed only a small vascular lumen (3 mm in diameter), due to its anatomical structure. In femoral blood concentrations of approx. 1 μg/L clenbuterol, approx. 56 μg/L stanozolol and approx. 8 μg/L metandienone, with trenbolone (<limit of quantification (LOQ)) were detected. Additionally, there were positive results in urine for boldenone, clomiphene, trenbolone, metandienone, stanozolol, clenbuterol and drostanolone, along with indications of testosterone and/or testosterone prohormones having been taken. In consideration of all aspects of this case, in can be assumed that the long-term consumption of anabolic androgen steroids (AAS) caused apparently pathological changes of the heart. Over and above, the combination of anatomical (small lumed coronary artery, ventricular hypertrophy) and substance-induced risk factors led to the fatal cardiovascular failure.

Parameters

Science
Case report
Date
8 August 2019
People
Andresen-Streichert, Hilke
Geyer, Hans
Glenewinkel, Frank
Juebner, Martin
Lehmann, Sabrina
Rothschild, Markus Alexander
Schiwy-Bochat, Karl-Heinz
Thevis, Mario
Thomas, Andreas
Country
Germany
Language
English
ADRV
Adverse Analytical Finding / presence
Sport/IFs
Bodybuilding & Fitness (IFBB) - International Federation of Bodybuilding & Fitness
Other organisations
Deutsche Sporthochschule Köln (DSHS) - German Sport University Cologne
Laboratories
Cologne, Germany: Institute of Biochemistry - German Sport University Cologne
Doping classes
S1. Anabolic Agents
S4. Hormone And Metabolic Modulators
Substances
Boldenone
Clenbuterol
Clomifene
Drostanolone
Methandienone (17β-hydroxy-17α-methylandrosta-1,4-dien-3-one)
Stanozolol
Testosterone
Trenbolone (17β-hydroxyestr-4,9,11-trien-3-one)
Medical terms
Athlete deceased
Cardiovascular diseases
Health effects
Heart disease
Long term effects
Document category
Abstract
Scientific article
Date generated
2 December 2020
Date of last modification
5 December 2020
Category
  • Legal Source
  • Education
  • Science
  • Statistics
  • History
Country & language
  • Country
  • Language
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  • ADRV
  • Legal Terms
  • Sport/IFs
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  • Laboratories
  • Analytical aspects
  • Doping classes
  • Substances
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