The Probenecid-story - A success in the fight against doping through out-of-competition testing

The Probenecid-story - A success in the fight against doping through out-of-competition testing / Peter Hemmersbach. - (Drug Testing and Analysis 12 (2020) 5 (May); p. 589-594)

  • PMID: 31797550
  • DOI: 10.1002/dta.2727


Abstract

The effectiveness of doping control in sport has been improved continuously during the past 50 years. One of the major steps forward was the introduction of unannounced and targeted out-of-competition testing in order to control the misuse of anabolic-androgenic steroids (AAS), mainly during the end of the 1980s. It also led to the misuse of masking agents in case a surprise control was performed. Athletes tried to be "prepared", when the doping control officer showed up. The disclosure of the masking agent probenecid in 1987 is a perfect example of a memorable finding, of a suspected and purported case of performance manipulation. Probenecid and its metabolites were identified in five urine samples collected from Norwegian athletes in an out-of-competition test, while they were staying and training in the USA. Probenecid is a drug that reduces the urinary excretion of AAS from the body. It was the first time that it had showed up in a doping control sample. The athletes were sanctioned for hampering the analysis of their urine sample, although probenecid was not yet specified on the Prohibited List. Its detection was the result of a successful collaboration of laboratories and investigative diligence and enthusiasm following up suspicious observations in the actual samples. Immediately afterwards probenecid was added to the Prohibited List for 1988 as well as including the manipulation of doping control samples.

Parameters

Science
Case report
Date
2 December 2019
People
Hemmersbach, Peter
Country
Norway
Language
English
ADRV
Tampering / attempted tampering
Legal Terms
Anti-Doping policy
Other organisations
Universitetet i Oslo - University of Oslo
Laboratories
Oslo, Norway: Norwegian Doping Control Laboratory
Doping classes
S5. Diuretics and Other Masking Agents
Substances
Probenecid
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Abstract
Date generated
15 March 2021
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  • Legal Source
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  • ADRV
  • Legal Terms
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  • Laboratories
  • Analytical aspects
  • Doping classes
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  • Various
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