Anabolic-androgenic steroid administration increases self-reported aggression in healthy males: a systematic review and meta-analysis of experimental studies

Anabolic-androgenic steroid administration increases self-reported aggression in healthy males : a systematic review and meta-analysis of experimental studies / Razieh Chegeni, Ståle Pallesen, Jim McVeigh, Dominic Sagoe. - (Psychopharmacology (2021, 20 March); p. 1-12)

  • PMID: 33745011
  • DOI: 10.1007/s00213-021-05818-7


Abstract

Rationale: Aggression and irritability are notable psychiatric side effects of anabolic-androgenic steroid (AAS) use. However, no previous study has systematically reviewed and quantitatively synthesized effects reported by experimental studies on this topic.

Objective: We conducted a systematic review and meta-analysis of randomized controlled trials (RCTs) investigating the effect of AAS administration on self-reported and observer-reported aggression.

Methods: Twelve RCTs comprising a total of 562 healthy males were identified through systematic searches of MEDLINE, PsycInfo, ISI Web of Science, ProQuest, Google Scholar, and the Cochrane Library.

Results: After excluding one outlier, AAS administration was associated with an increase in self-reported aggression under a random-effects model, albeit small (Hedges' g = 0.171, 95% CI: 0.029-0.312, k = 11, p = .018), and when restricting the analysis to the effect of acute AAS administration on self-reported aggression under a fixed-effect model (g = 0.291, 95% CI: 0.014-0.524, p = .014). However, the above effects were neither replicated in the analysis of observer-reported aggression nor after restricting the analysis to the effects of the administration of higher (over 500 mg) and long-term (3 days to 14 weeks) doses.

Conclusions: The present meta-analysis provides evidence of an increase, although small, in self-reported aggression in healthy males following AAS administration in RCTs. Ecologically rational RCTs are warranted to better explore the effect of AAS administration on aggression in humans.

Original document

Parameters

Science
Review
Date
20 March 2021
People
Chegeni, Razieh
McVeigh, Jim
Pallesen, Ståle
Sagoe, Dominic
Country
Norway
Other organisations
Manchester Metropolitan University (MMU)
North-West University (NWU)
Universitetet i Bergen - University of Bergen
Doping classes
S1. Anabolic Agents
Medical terms
Health effects
Document category
Scientific article
Document type
Pdf file
Date generated
22 March 2021
Date of last modification
1 April 2021
Category
  • Legal Source
  • Education
  • Science
  • Statistics
  • History
Country & language
  • Country
  • Language
Other filters
  • ADRV
  • Legal Terms
  • Sport/IFs
  • Other organisations
  • Laboratories
  • Analytical aspects
  • Doping classes
  • Substances
  • Medical terms
  • Various
  • Version
  • Document category
  • Document type
Publication period
Origin