Androgens in postmenopausal women: production, possible role, and replacement options

Androgens in postmenopausal women : production, possible role, and replacement options / R A Lobo. - (Obstetrical & Gynecological Survey 56 (2001) 6 (June); p. 361-376)

  • PMID: 11466487
  • DOI: 10.1097/00006254-200106000-00022


Abstract

The physiology of normal androgen production in women has not been well understood. Aging, per se, accounts for much of the reduction in both ovarian and adrenal androgen production; and natural menopause does not result in an abrupt decline in testosterone production. Therefore, the definition of an androgen deficiency state in women, in the absence of adrenal suppression and/or bilateral oophorectomy, has been difficult. Nevertheless there are well-documented beneficial effects of androgen on many organ systems, including bone and the brain. This review focuses on the physiology of androgens in postmenopausal women and includes a discussion of the definition of an androgen deficiency state, the anticipated effects of androgen on several parameters of health, and possible ways in which androgens may be administered to women.

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Date
1 June 2001
People
Lobo, Rogerio A.
Country
United States of America
Language
English
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Columbia University Vagelos College of Physicians and Surgeons (VP&S)
Substances
Androstenedione (androst-4-ene-3,17-dione)
Methyltestosterone
Prasterone (dehydroepiandrosterone, DHEA, 3β-hydroxyandrost-5-en-17-one)
Testosterone
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Health effects
Hormone replacement therapy (HRT)
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Scientific article
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Date generated
31 March 2021
Date of last modification
15 April 2021
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