Do dried blood spots have the potential to support result management processes in routine sports drug testing? - Part 2: Proactive sampling for follow‐up investigations concerning atypical or adverse analytical findings

Do dried blood spots have the potential to support result management processes in routine sports drug testing?-Part 2: Proactive sampling for follow-up investigations concerning atypical or adverse analytical findings / Mario Thevis, Tiia Kuuranne, Andreas Thomas, Hans Geyer. - ( Drug Testing and Analysis 13 (2021) 3 (March); p. 505-509)

  • PMID: 33538088
  • DOI: 10.1002/dta.3011


Abstract

Capillary blood sampled as dried blood spot (DBS) has shown substantial potential as test matrix in sports drug testing in various different settings, enabling the analysis of numerous different drugs and/or their respective metabolites. In addition to established beneficial aspects of DBS specimens in general (such as the minimally invasive and non-intrusive nature, and simplified sample transport), a yet unexplored advantage of DBS in the anti-doping context could be the opportunity of preserving a source of information complementary to routine doping controls performed in urine or venous blood. Whenever follow-up investigations are warranted or required, frequently collected and stored (but yet not analyzed) DBS samples could be target-tested for the compound(s) in question, in order to contribute to results management and decision-making processes.

Keywords: adverse analytical finding; atypical finding; doping; dried blood spot; sport.

Original document

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Date
11 February 2021
People
Geyer, Hans
Kuuranne, Tiia
Thevis, Mario
Thomas, Andreas
Other organisations
Deutsche Sporthochschule Köln (DSHS) - German Sport University Cologne
European Monitoring Centre for Drugs and Drug Addiction (EMCDDA)
Laboratories
Lausanne, Switzerland: Laboratoire Suisse d’Analyse du Dopage
Analytical aspects
Blood testing method
Testing method development
Doping classes
S6. Stimulants
S9. Glucocorticosteroids
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Cocaine
Prednisolone
Prednisone
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Scientific article
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22 April 2021
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4 May 2021
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