Synthesis and anabolic/androgenic evaluation of novel 9α-fluorosteroids / M. Reyes-Moreno, J.A. Ruiz-García, Y. Ibarra-Reyes, A. Fuente-Hernández, H. Vélez-Castro, I. Hernández-Balmaseda, I. Martínez-Hormaza, I. Rodeiro-Guerra, J. Sandoval Ramírez, S. Meza Reyes, S. Montiel-Smith. - (European Journal of Medicinal Chemistry 44 (2009) 11 (November); p. 4567-4571)
- PMID: 19615789
- DOI: 10.1016/j.ejmech.2009.06.025
Abstract
3Beta,11beta-dihydroxy-9alpha-fluor-5alpha-androstane-17-one (2), 3beta-acetoxy-9alpha-fluor-11beta-hydroxy-5alpha-androstane-17-one (3), 3beta-acetoxy-9alpha-fluor-11beta,17beta-dihydroxy-5alpha-androstane (4), 3beta,17beta-diacetoxy-9alpha-fluor-11beta-hydroxy-5alpha-androstane (5), 3beta-acetoxy-9alpha-fluor-11beta-hydroxy-5alpha-androstane 17beta-propionate (6), 3beta-acetoxy-9alpha-fluor-11beta-hydroxy-5alpha-androstane 17beta-enanthate (7), 3beta-acetoxy-9alpha-fluor-11beta-hydroxy-5alpha-androstane 17beta-isobutyrate (8) were synthesized in the present study. Compounds 2 and 8 exhibited higher anabolic activity than the rest of the synthesized compounds. The structure of all these newly synthesized compounds was confirmed by analytic spectral data (mass, (1)H NMR and (13)C NMR).
