Synthesis and anabolic/androgenic evaluation of novel 9α-fluorosteroids

Synthesis and anabolic/androgenic evaluation of novel 9α-fluorosteroids / M. Reyes-Moreno, J.A. Ruiz-García, Y. Ibarra-Reyes, A. Fuente-Hernández, H. Vélez-Castro, I. Hernández-Balmaseda, I. Martínez-Hormaza, I. Rodeiro-Guerra, J. Sandoval Ramírez, S. Meza Reyes, S. Montiel-Smith. - (European Journal of Medicinal Chemistry 44 (2009) 11 (November); p. 4567-4571)

  • PMID: 19615789
  • DOI: 10.1016/j.ejmech.2009.06.025


Abstract

3Beta,11beta-dihydroxy-9alpha-fluor-5alpha-androstane-17-one (2), 3beta-acetoxy-9alpha-fluor-11beta-hydroxy-5alpha-androstane-17-one (3), 3beta-acetoxy-9alpha-fluor-11beta,17beta-dihydroxy-5alpha-androstane (4), 3beta,17beta-diacetoxy-9alpha-fluor-11beta-hydroxy-5alpha-androstane (5), 3beta-acetoxy-9alpha-fluor-11beta-hydroxy-5alpha-androstane 17beta-propionate (6), 3beta-acetoxy-9alpha-fluor-11beta-hydroxy-5alpha-androstane 17beta-enanthate (7), 3beta-acetoxy-9alpha-fluor-11beta-hydroxy-5alpha-androstane 17beta-isobutyrate (8) were synthesized in the present study. Compounds 2 and 8 exhibited higher anabolic activity than the rest of the synthesized compounds. The structure of all these newly synthesized compounds was confirmed by analytic spectral data (mass, (1)H NMR and (13)C NMR).

Original document

Parameters

Science
Study
Date
1 July 2009
People
Fuente-Hernández, A.
Ibarra-Reyes, Y.
Meza Reyes, S.
Montiel-Smith, S.
Reyes-Moreno, M.
Rodeiro-Guerra, I.
Ruiz-Garcia, J.A.
Sandoval Ramírez, J.
Country
Cuba
Mexico
Language
English
Other organisations
Benemérita Universidad Autónoma de Puebla (BUAP) - Meritorious Autonomous University of Puebla
Centro de Química Farmacéutica (CQF)
Doping classes
S1. Anabolic Agents
Document category
Scientific article
Document type
Pdf file
Date generated
22 April 2021
Date of last modification
4 May 2021
Category
  • Legal Source
  • Education
  • Science
  • Statistics
  • History
Country & language
  • Country
  • Language
Other filters
  • ADRV
  • Legal Terms
  • Sport/IFs
  • Other organisations
  • Laboratories
  • Analytical aspects
  • Doping classes
  • Substances
  • Medical terms
  • Various
  • Version
  • Document category
  • Document type
Publication period
Origin