Effects of Exogenous Androgens on Platelet Activity and Their Thrombogenic Potential in Supraphysiological Administration: A Literature Review

Effects of Exogenous Androgens on Platelet Activity and Their Thrombogenic Potential in Supraphysiological Administration : A Literature Review / Adrian Eugen Roşca, Ana-Maria Vlădăreanu, Alina Mititelu, Bogdan Ovidiu Popescu, Corin Badiu, Constantin Căruntu, Suzana Elena Voiculescu, Minodora Onisâi, Şerban Gologan, Radu Mirica, Leon Zăgrean. - (Journal of Clinical Medicine 10 (2021) 1 (4 January); p. 1-27)

  • PMID: 33406783
  • PMCID: PMC7795962
  • DOI: 10.3390/jcm10010147


Anabolic androgenic steroids (AAS), simply called "androgens", represent the most widespread drugs used to enhance performance and appearance in a sporting environment. High-dosage and/or long-term AAS administration has been associated frequently with significant alterations in the cardiovascular system, some of these with severe endpoints. The induction of a prothrombotic state is probably the most life-threatening consequence, suggested by numerous case reports in AAS-abusing athletes, and by a considerable number of human and animal studies assessing the influence of exogenous androgens on hemostasis. Despite over fifty years of research, data regarding the thrombogenic potential of exogenous androgens are still scarce. The main reason is the limited possibility of conducting human prospective studies. However, human observational studies conducted in athletes or patients, in vitro human studies, and animal experiments have pointed out that androgens in supraphysiological doses induce enhanced platelet activity and thrombopoiesis, leading to increased platelet aggregation. If this tendency overlaps previously existing coagulation and/or fibrinolysis dysfunctions, it may lead to a thrombotic diathesis, which could explain the multitude of thromboembolic events reported in the AAS-abusing population. The influence of androgen excess on the platelet activity and fluid-coagulant balance remains a subject of debate, urging for supplementary studies in order to clarify the effects on hemostasis, and to provide new compelling evidence for their claimed thrombogenic potential.

Original document


4 January 2021
Badiu, Corin
Căruntu, Constantin
Gologan, Şerban
Mirica, Radu
Mititelu, Alina
Onisâi, Minodora
Popescu, Bogdan Ovidiu
Roşca, Adrian Eugen
Vlădăreanu, Ana-Maria
Voiculescu, Suzana Elena
Zăgrean, Leon
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Institutul de Diabet, Nutriţie şi Boli Metabolice N.C. Paulescu - Institute of Diabetes, Nutrition and Metabolic Diseases
Institutul Național de Cercetare-Dezvoltare în Domeniul Patologiei și Științelor Biomedicale Victor Babeș - Victor Babes National Institute of Pathology (INCDVB)
Universitatea de Medicină și Farmacie Carol Davila - Carol Davila University of Medicine and Pharmacy
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4 May 2021
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28 May 2021
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