Metabolism of anabolic androgenic steroids

Metabolism of anabolic androgenic steroids / W. Schänzer. - (Clinical Chemistry 42 (1996) 7 (July); p. 1001-1020)

  • PMID: 8674183
  • DOI: 10.1093/clinchem/42.7.1001


Abstract

Anabolic androgenic steroids (AAS) are misused to a high extent in sports by athletes to improve their physical performance. Sports federations consider the use of these drugs in sports as doping. The misuse of AAS is controlled by detection of the parent AAS (when excreted into urine) and (or) their metabolites in urine of athletes. I present a review of the metabolism of AAS. Testosterone is the principal androgenic steroid and its metabolism is compared with that of AAS. The review is divided into two parts: the general metabolism of AAS, which is separated into phase I and phase II metabolism and includes a systematic discussion of metabolic changes in the steroid molecule according to the regions (A-D rings), and the specific metabolism of AAS, which presents the metabolism of 26 AAS in humans.

Original document

Parameters

Science
Review
Date
1 July 1996
People
Schänzer, Wilhelm
Country
Germany
Language
English
Other organisations
Deutsche Sporthochschule Köln (DSHS) - German Sport University Cologne
Analytical aspects
Metabolization
Doping classes
S1. Anabolic Agents
Substances
Testosterone
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Current
Document category
Scientific article
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Date generated
28 July 2021
Date of last modification
29 July 2021
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