No pain, just gain: Painless, easy, and fast dried blood spot collection from fingertip and upper arm in doping control

No pain, just gain : Painless, easy, and fast dried blood spot collection from fingertip and upper arm in doping control / Sara Amalie Solheim, Thomas Kamm Ringsted, Nikolai B. Nordsborg, Yvette Dehnes, Maren Christin Stillesby Levernaes, Jakob Mørkeberg. - (Drug Testing and Analysis (2021) 3 August; 3135)

  • PMID: 34346172
  • DOI: 10.1002/dta.3135


This study aimed to determine and compare the perception, painfulness, and usability of the minimally invasive dried blood spot (DBS) collections from fingertip versus upper arm from different athlete populations: males and females representing sports dependent on hand/arm, sports less dependent on hand/arm and para-athletes. To accomplish this, 108 national level athletes from Denmark were recruited (♀ = 49, ♂ = 59, 25 ± 6 years; mean ± SD) and 11 Doping Control Officers (DCOs) collected manual fingerprick DBS (HemaSpot HF) and automated upper-arm DBS (Tasso-M20) from each athlete. Athletes and DCOs responded to questionnaires regarding the perception of sample collection procedures. On a 0-10 scale, the athletes reported a low pain score and a very good general experience for both sampling sites, but following upper-arm DBS collection, the associated pain was rated lower (-0.4 ± 1.6, p < 0.05), and the general experience rated better (+0.6 ± 2.3, p ≤ 0.001) than after the fingerprick DBS collection. The DCOs rated the general experience with the upper-arm DBS collection better (+1.6 ± 1.1, p ≤ 0.01) than the fingerprick DBS collection, partly because problems occurred more frequently during the DBS collection from the fingertip (28%) than from the upper arm (6%). In conclusion, it appears that DBS sampling is affiliated with minimal sensation of pain and is preferred by both DCOs and athletes, independent of gender and discipline, over conventional sample collection methods. Collection of DBS from the upper arm was preferred over fingerprick by both athletes and DCOs.


Research / Study
3 August 2021
Dehnes, Yvette
Mørkeberg, Jakob
Nordsborg, Nikolai Baastrup
Ringsted, Thomas Kamm
Solheim, Sara Amalie
Stillesby, Maren Christin
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Anti-Doping Denmark (ADD)
Københavns Universitet - University of Copenhagen (UCPH)
Oslo, Norway: Norwegian Doping Control Laboratory
Analytical aspects
Blood testing method
Blood Sample Collection
Doping control
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Date generated
30 August 2021
Date of last modification
1 September 2021
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