Is There Room for SERMs or SARMs as Alternative Therapies for Adult Male Hypogonadism?

Is There Room for SERMs or SARMs as Alternative Therapies for Adult Male Hypogonadism? / Vito A Giagulli, Andrea Silvestrini, Carmine Bruno, Vincenzo Triggiani, Alvaro Mordente, Antonio Mancini. - (International Journal of Endocrinology (2020) 21 January)

  • PMID: 32411230
  • PMCID: PMC7201459
  • DOI: 10.1155/2020/9649838


Hypogonadotropic hypogonadism (HH) can be sustained by organic or functional alterations of the hypothalamic-pituitary-testicular axis. Functional HH is related to systemic alterations, such as obesity or chronic inflammatory diseases, but could contribute to a negative course of the illness. For such situation, according to results obtained in infertile women, the administration of selective estrogen receptor modulators (SERMs) has been proposed in males too, with positive results on both metabolic and sexual function. This class of medications increases gonadotropin levels via antagonism to the estrogenic receptor; similar biological effects are also exerted by aromatase inhibitors (AIs), despite different mechanism of action. After a brief review of trials regarding SERMs and AIs use in male HH, we describe the structure and function of the androgen receptor (AR) as a basis for clinical research about compounds able to bind to AR, in order to obtain specific effects (SARMs). The tissue selectivity and different metabolic fate in comparison to testosterone can potentiate anabolic versus androgenic effects; therefore, they might be a valid alternative to testosterone replacement therapy avoiding the negative effects of testosterone (i.e., on prostate, liver, and hematopoiesis). Trials are still at an early phase of investigation and, at the moment, the application seems to be more useful for chronic disease with catabolic status while the validation as replacement for hypogonadism requires further studies.

Original document


Research / Study
21 January 2020
Bruno, Carmine
Giagulli, Vito A
Mancini, Antonio
Mordente, Alvaro
Silvestrini, Andrea
Triggiani, Vincenzo
Other organisations
Università Cattolica del Sacro Cuore (UCSC) - Catholic University of the Sacred Heart
Università degli Studi di Bari Aldo Moro - University of Bari Aldo Moro
Doping classes
S1. Anabolic Agents
Enobosarm (ostarine)
LGD-4033 (ligandrol)
Selective androgen receptor modulators (SARMs)
Medical terms
Hormone replacement therapy (HRT)
Legitimate Medical Treatment
Document category
Scientific article
Document type
Pdf file
Date generated
28 October 2021
Date of last modification
3 November 2021
  • Legal Source
  • Education
  • Science
  • Statistics
  • History
Country & language
  • Country
  • Language
Other filters
  • ADRV
  • Legal Terms
  • Sport/IFs
  • Other organisations
  • Laboratories
  • Analytical aspects
  • Doping classes
  • Substances
  • Medical terms
  • Various
  • Version
  • Document category
  • Document type
Publication period