Testosterone dose-response relationships in healthy young men

Testosterone dose-response relationships in healthy young men / S. Bhasin, L. Woodhouse, R Casaburi, A.B. Singh, D. Bhasin, N. Berman, X. Chen, K.E. Yarasheski, L. Magliano, C. Dzekov, J. Dzekov, R. Bross, J. Phillips, I. Sinha-Hikim, R. Shen, T.W. Storer

  • American journal of physiology. Endocrinology and metabolism 281 (2001) 6 (December), p. E1172-E1181
  • PMID: 11701431
  • DOI: 10.1152/ajpendo.2001.281.6.E1172


Abstract

Testosterone increases muscle mass and strength and regulates other physiological processes, but we do not know whether testosterone effects are dose dependent and whether dose requirements for maintaining various androgen-dependent processes are similar. To determine the effects of graded doses of testosterone on body composition, muscle size, strength, power, sexual and cognitive functions, prostate-specific antigen (PSA), plasma lipids, hemoglobin, and insulin-like growth factor I (IGF-I) levels, 61 eugonadal men, 18-35 yr, were randomized to one of five groups to receive monthly injections of a long-acting gonadotropin-releasing hormone (GnRH) agonist, to suppress endogenous testosterone secretion, and weekly injections of 25, 50, 125, 300, or 600 mg of testosterone enanthate for 20 wk. Energy and protein intakes were standardized. The administration of the GnRH agonist plus graded doses of testosterone resulted in mean nadir testosterone concentrations of 253, 306, 542, 1,345, and 2,370 ng/dl at the 25-, 50-, 125-, 300-, and 600-mg doses, respectively. Fat-free mass increased dose dependently in men receiving 125, 300, or 600 mg of testosterone weekly (change +3.4, 5.2, and 7.9 kg, respectively). The changes in fat-free mass were highly dependent on testosterone dose (P = 0.0001) and correlated with log testosterone concentrations (r = 0.73, P = 0.0001). Changes in leg press strength, leg power, thigh and quadriceps muscle volumes, hemoglobin, and IGF-I were positively correlated with testosterone concentrations, whereas changes in fat mass and plasma high-density lipoprotein (HDL) cholesterol were negatively correlated. Sexual function, visual-spatial cognition and mood, and PSA levels did not change significantly at any dose. We conclude that changes in circulating testosterone concentrations, induced by GnRH agonist and testosterone administration, are associated with testosterone dose- and concentration-dependent changes in fat-free mass, muscle size, strength and power, fat mass, hemoglobin, HDL cholesterol, and IGF-I levels, in conformity with a single linear dose-response relationship. However, different androgen-dependent processes have different testosterone dose-response relationships.

Original document

Parameters

Science
Research / Study
Date
1 December 2001
People
Berman, Nancy
Bhasin, Dimple
Bhasin, Shalender
Bross, Rachelle
Casaburi, Richard
Chen, Xianghong
Dzekov, Connie
Dzekov, Jeanne
Magliano, Lynne
Phillips, Jeffrey
Shen, Ruoquing
Singh, Atam B.
Sinha-Hikim, Indrani
Storer, Thomas W.
Woodhouse, Linda J.
Yarasheski, Kevin E.
Country
United States of America
Language
English
Other organisations
Charles R. Drew University of Medicine and Science
Harbor-UCLA Medical Center
Washington University in St. Louis (WUSTL)
Doping classes
S1. Anabolic Agents
Substances
Testosterone
Medical terms
Health effects
Document type
Pdf file
Date generated
20 June 2022
Date of last modification
26 July 2022
Category
  • Legal Source
  • Education
  • Science
  • Statistics
  • History
Country & language
  • Country
  • Language
Other filters
  • ADRV
  • Legal Terms
  • Sport/IFs
  • Other organisations
  • Laboratories
  • Analytical aspects
  • Doping classes
  • Substances
  • Medical terms
  • Various
  • Version
  • Document category
  • Document type
Publication period
Origin