Annual banned-substance review: analytical approaches in human sports drug testing - [2021-2022]

Annual banned-substance review: analytical approaches in human sports drug testing / Mario Thevis, Tiia Kuuranne, Hans Geyer

  • Drug Testing and Analysis 14 (2022) 11 November
  • PMID: 36369629
  • DOI: 10.1002/dta.3408


  • Introduction
  • Anabolic Agent
    • Anabolic-androgenic steroids (AASs)
    • Initial testing procedures (ITP): Comprehensive screening, metabolism studies
    • Other anabolic agents
    • Steroid profiling in urine and blood
    • Confirmatory testing procedures – IRMS
  • Peptide Hormones, Growth Factors, Related Substances, and Mimetics
    • Erythropoietin-receptor agonists
    • Growth hormone (GH), its fragments and releasing factors
  • β2‐Agonists, Hormone and Metablolic Modulators, and diuretics
  • Stimulants, Glucocorticoids, and Cannabinoids
  • Manipulation of blood and blood components
  • Chemical and Physical Manipulation and Gene Doping
  • Conclusion


Also in 2021/2022, considerable efforts were invested into advancing human sports drug testing programs, recognizing and taking into account existing as well as emerging challenges in anti-doping, especially with regard to substances and methods of doping specified in the World Anti-Doping Agency's 2022 Prohibited List. In this edition of the annual banned-substance review, literature on recent developments published between October 2021 and September 2022 is summarized and discussed. Focus is put particularly on enhanced analytical approaches and complementary testing options in human doping controls, appreciating the exigence and mission in anti-doping and, equally, the contemporary “new normal” considering, for example, the athlete's exposome versus analytical sensitivity and applicable anti-doping regulations for result interpretation and management.

Original document


11 November 2022
Geyer, Hans
Kuuranne, Tiia
Thevis, Mario
Other organisations
Centre Hospitalier Universitaire Vaudois (CHUV) - Lausanne University Hospital
Deutsche Sporthochschule Köln (DSHS) - German Sport University Cologne
European Monitoring Center for Emerging Doping Agents (EuMoCEDA)
Cologne, Germany: Institute of Biochemistry - German Sport University Cologne
Lausanne, Switzerland: Laboratoire Suisse d’Analyse du Dopage
Analytical aspects
Mass spectrometry analysis
Doping classes
M1. Manipulation Of Blood And Blood Components
M2. Chemical And Physical Manipulation
M3. Gene And Cell Doping
P1. Beta-Blockers
S0. Non-Approved Substances
S1. Anabolic Agents
S2. Peptide Hormones, Growth Factors
S3. Beta-2 Agonists
S4. Hormone And Metabolic Modulators
S5. Diuretics and Other Masking Agents
S6. Stimulants
S7. Narcotics
S8. Cannabinoids
S9. Glucocorticosteroids
Medical terms
Substance use research
Document category
Scientific article
Document type
Pdf file
Date generated
1 November 2022
Date of last modification
24 November 2022
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