AMPK and PPARdelta agonists are exercise mimetics.

31 Jul 2008

Narkar VA, Downes M, Yu RT, Embler E, Wang YX, Banayo E, Mihaylova MM, Nelson MC, Zou Y, Juguilon H, Kang H, Shaw RJ, Evans RM. AMPK and PPARdelta agonists are exercise mimetics. Cell. 2008 Aug 8;134(3):405-15. Epub 2008 Jul 31.

Caffeine and ephedrine: physiological, metabolic and performance-enhancing effects.

1 Dec 2004

Magkos F, Kavouras SA. Caffeine and ephedrine: physiological, metabolic and performance-enhancing effects. Sports Med. 2004;34(13):871-89.

Effects of acute modafinil ingestion on exercise time to exhaustion.

1 Jun 2004

Jacobs I, Bell DG. Effects of acute modafinil ingestion on exercise time to exhaustion. Med Sci Sports Exerc. 2004 Jun;36(6):1078-82.

Cannabis in sport: anti-doping perspective.

1 Nov 2011

Huestis MA, Mazzoni I, Rabin O. Cannabis in sport: anti-doping perspective. Sports Med. 2011 Nov 1;41(11):949-66. doi: 10.2165/11591430-000000000-00000.

Marijuana as doping in sports.

1 Jun 2003

Campos DR, Yonamine M, de Moraes Moreau RL. Marijuana as doping in sports. Sports Med. 2003;33(6):395-9.

Indirect androgen doping by oestrogen blockade in sports.

21 Apr 2008

Indirect androgen doping by oestrogen blockade in sports / D.J. Handelsman

  • British Journal of Pharmacology 154 (2008) 3 (June), p. 598-605
  • PMID: 18500381
  • PMCID: PMC2439522
  • DOI: 10.1038/bjp.2008.150


Abstract

Androgens can increase muscular mass and strength and remain the most frequently abused and widely available drugs used in sports doping. Banning the administration of natural or synthetic androgens has led to a variety of strategies to circumvent the ban of the most effective ergogenic agents for power sports. Among these, a variety of indirect androgen doping strategies aiming to produce a sustained rise in endogenous testosterone have been utilized. These include oestrogen blockade by drugs that act as oestrogen receptor antagonists (antioestrogen) or aromatase inhibitors. The physiological and pharmacological basis for the effects of oestrogen blockade in men, but not women, are reviewed.

The effect of desmopressin, a vasopressin analog, on endurance performance during a prolonged run in simulated heat conditions.

1 Apr 2006

Ftaiti F, Dantin MP, Nicol C, Brunet C, Grélot L. The effect of desmopressin, a vasopressin analog, on endurance performance during a prolonged run in simulated heat conditions. Appl Physiol Nutr Metab. 2006 Apr;31(2):135-43.

Physiological and pharmacological basis for the ergogenic effects of growth hormone in elite sports.

1 May 2008

Ehrnborg C, Rosén T. Physiological and pharmacological basis for the ergogenic effects of growth hormone in elite sports. Asian J Androl. 2008 May;10(3):373-83.

Supraphysiological growth hormone: less fat, more extracellular fluid but uncertain effects on muscles in healthy, active young adults.

1 Apr 2005

Ehrnborg C, Ellegård L, Bosaeus I, Bengtsson BA, Rosén T. Supraphysiological growth hormone: less fat, more extracellular fluid but uncertain effects on muscles in healthy, active young adults. Clin Endocrinol (Oxf). 2005 Apr;62(4):449-57.

CAS 2008_A_1565 WADA vs Frederico Turrini & CISM

4 Nov 2008

CAS 2008/A/1565 World Anti-Doping Agency (WADA) v. International Military Sports Council (CISM) & Federico Turrini

Related case:
Swiss Federal Court 4A_10_2009 Federico Turrini vs WADA & CISM
July 8, 2009

Aquatics (swimming)
Doping (19-norandrosterone)
Dies a quo of the time limit for the filing of the appeal
Presence of a prohibited substance
Conditions of reduction of the period of ineligibility based on exceptional circumstances
Determination of the disciplinary sanction

1. It is very important that international sports law rules are equally applied for all parties, no matter if they are athletes or organizations, and that the application also must be foreseeable for those involved. If a party which have not taken part in the proceedings leading to the appealed decision shall have a fair opportunity to file an appeal it must be aware of that decision. In spite of the wording of the applicable rule, according to the applicable procedural rules, international sport law and CAS case law, the time limit for the filing of the appeal should not be counted from the date when the decision has been made, but when the party appealing the decision has been notified of such decision. In any event, it is for the respondent to prove that the decision was communicated more than 21 days prior to the appellant’s statement of appeal.

2. The presence of 19-norandrosterone which is an endogenous anabolic androgenic steroid at a concentration greater than 2 ng/ml in an athlete’s bodily specimen constitutes a doping violation incompatible with an endogenous production of the substance.

3. It is the professional duty of an athlete to consult the rules and to be well aware of all the duties an athlete has to fulfil. In this respect, an athlete must be active to ensure that no prohibited substance enters his/her body. As said in the Commentary to WADC, an athlete cannot rely on advice from his/her personal physician in these matters, especially when the doctor is no expert on sports medicine. The fact that an athlete is a professional is also relevant. If the athlete has not done anything to ensure this, s/he has not established that he bears no significant fault or negligence. There is therefore no ground to reduce the sanction on this basis.

4. It is well established that a two-year suspension for a first time doping offence is legally acceptable. Pursuant to the rules, the period of provisional suspension voluntarily accepted by an athlete shall be credited against the total period of ineligibility to be served. Furthermore, it is required by fairness that the starting date of the period of ineligibility should not constitute a disadvantage for the athlete when the process from the sample collection to the date when the sanction can be imposed has been far too long.


On 15 January 2008 the International Military Sports Council (CISM) decided to impose a suspended sanction of 2 years on the Italian swimmer Frederico Turrini after his sample tested positive for the prohibited substance 19-norandrosterone (Nandrolone).
Here the Athlete denied the intentional, accepted the test result and explained that the postitive test was caused by prescribed eye drops that contained the prohibited substance.

Hereafter in May 2008 the World Anti-Doping Agency (WADA) appeled the CISM decision with the Court of Arbitration for Sport (CAS). WADA requested the Panel to set aside the CISM decision of 15 January 2008 and to impose a 2 year period of ineligibility on the Athlete.

The Panel concludes that the Athlete committed an anti-doping rule violation and that he failed to establish that he bears No Significant Fault or Negligence. The Panel finds that the Athlete, in order to fulfil his or her duty according to Art. 2.1. of the WADC, has to be active to ensure that a medication that he or she uses does not contain any compound that is on the Prohibited List. In the present case, the Athlete has not done anything to ensure this.

Therefore the Court of Arbitration for Sport decides on 4 November 2008 that:

(1) The appeal filed by WADA on 30 May 2008 is admissible.
(2) The decision of CISM Discipline Commission dated 15 January 2008 in the matter of Federico Turrini. is set aside,
(3) Federico Turrini is sanctioned by a two (2) years ineligibility, which started on 6 February 2008. The period of voluntary suspension from 3 December 2007 to 5 February 2008 shall be credited against the total period of ineligibility to be served.
(4) All competitive results obtained by Federico Turrini from 19 October 2007 until the date of the present decision shall be disqualified with all of the resulting consequences including forfeiture of any medals, points and prizes.
(5) All other prayers for relief are dismissed.
(6) The award is pronounced without costs except for the Court Office fee of CHF 500,- (five hundred Swiss Francs) paid by Mr Federico Turrini and which is kept by the CAS.
(7) Each party shall boar its own costs.

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