Scientific Opinion on the Regulatory Status of 1,3-Dimethylamylamine (DMAA) / Bastiaan J. Venhuis, Dries de Kaste. – (European Journal of Food Research & Review 2 (2012) 4 (November 26) : p. 93-100)
Content:
- Introduction
- Nomenclature
- Pharmacology
- Intranasal Application
- Oral Application
- Discussion
• Effect on the heart
• Effect on the Blood Pressure
• Effect on the Lungs and the Nose
- Conclusion
1,3-Dimethylamylamine (DMAA) is a pressor amine often found in food supplements for athletes at dosages of 25-65 mg. Historically, the compound has been used as a nasal decongestant but its oral application is largely unstudied leaving the regulatory status of such food supplements as unlicensed medicines undetermined. We therefore reviewed the literature on DMAA and similar amines in order to deduce an effective oral dosage. Based on our findings we conclude that oral preparations with >4 mg DMAA per dose unit should be considered as effective as a bronchodilator. Food supplements that exceed that limit are in fact subject to the Medicines Act and require licensing. Dosages higher than 100-200 mg are expected to cause serious adverse events.
