The Effects of Inhaled Terbutaline on 3-km Running Time-Trial Performance

The Effects of Inhaled Terbutaline on 3-km Running Time-Trial Performance / John Molphy, John W. Dickinson, Neil J. Chester, Mike Loosemore, Gregory Whyte. - (International journal of sports physiology and performance (2018, 20 Dec) p. 1-26).
- PMID: 30569748.
- DOI: 10.1123/ijspp.2018-0633
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Abstract:

PURPOSE::
To investigate the effects of two therapeutic (2mg; 4mg) inhaled doses of terbutaline on 3km running time-trial performance.

METHODS::
Eight males (24.3±2.4yrs; 77.6±8kg; 179.5±4.3cm) and eight females (22.4±3yrs; 58.6±6kg; 163±9.2cm) free from respiratory disease and illness provided written informed consent. Participants completed 3 km running time-trials on a non-motorised treadmill on three separate occasions following placebo, 2 mg or 4 mg inhaled terbutaline, in a single-blind, repeated-measures design. Urine samples (15mins post-exercise) were analysed for terbutaline concentration. Data were analysed using one-way repeated measures ANOVA, significance was set at p<0.05 for all analyses.

RESULTS::
No differences were observed for completion times (1103±201; 1106±195; 1098±165s; P=0.913) for the placebo trial, the 2mg inhaled trial and the 4mg inhaled trial, respectively. Lactate values were higher (P=0.02) following 4mg terbutaline (10.7±2.3mmol·L-1) vs. placebo (8.9±1.8mmol·L-1). FEV1 values were greater following inhalation of 2mg (5.08±0.2; P=0.01) and 4mg terbutaline (5.07±0.2; P=0.02) compared to placebo (4.83±0.5L) post-inhalation. Urinary terbutaline concentrations were mean (306±288ng·mL-1; 435±410ng·mL-1; P=0.2) and peak (956ng·mL-1; 1244ng·mL-1) following 2mg and 4mg inhaled terbutaline, respectively. No differences were observed between the male and female participants.

CONCLUSIONS::
Therapeutic dosing of terbutaline does not lead to an improvement in 3 km running performance despite significantly increased FEV1. Our findings suggest that athletes using inhaled terbutaline at high therapeutic doses to treat asthma will not gain an ergogenic advantage during 3 km running performance.

Parameters:

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Study
Date:
20 December 2018
People
Chester, Neil J.
Dickinson, John W.
Loosemore, Mike
Molphy, John
Whyte, Gregory
Country
United Kingdom
Language
English
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Liverpool John Moores University (LJMU)
University College London (UCL)
University of Kent
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S3. Beta-2 Agonists
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Terbutaline
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