Pharmacokinetic Evaluation of Three Different Intramuscular Doses of Nandrolone Decanoate : Analysis of Serum and Urine Samples in Healthy Men

Pharmacokinetic Evaluation of Three Different Intramuscular Doses of Nandrolone Decanoate : Analysis of Serum and Urine Samples in Healthy Men / Wilma M. Bagchus, Jean M.W. Smeets, Herman A.M. Verheul, Suzanne M. De Jager-Van Der Veen, Andreas Port, T.B. Paul Geurts. - (Journal of Clinical Endocrinology & Metabolism 90 (2005) 5 (1 May); p. 2624-2630).
- PMID: 15713722.
- DOI: 10.1210/jc.2004-1526


Abstract

The pharmacokinetics of nandrolone in serum and urine were investigated in healthy young men after a single im injection of 50 mg (n = 20), 100 mg (n = 17), or 150 mg (n = 17) nandrolone decanoate. Blood samples were collected before treatment and for up to 32 d after dosing. In addition, in the 50- and 150-mg groups, 24-h urine samples were collected before treatment and on d 1, 7, and 33 after treatment; in the 150-mg group, additional samples were collected after 3 and 6 months. Serum concentrations and the area under the curve of nandrolone increased proportionally with the dose administered. The peak serum concentration ranged from 2.14 ng/ml in the 50-mg group to 4.26 ng/ml in the 100-mg group and 5.16 ng/ml in the 150-mg group. The peak serum concentration was reached after 30 h (50 and 100 mg) and 72 h (150 mg), whereas the terminal half-life was 7-12 d. In urine, pretreatment concentrations of 19-norandrosterone (19-NA) and/or 19-noretiocholanolone (19-NE) were detected in five of 37 subjects (14%). In the 50-mg group, 19-NA and/or 19-NE could be detected at least until 33 d after injection in 16 of 17 subjects (94%). In the 150-mg group, who were presumed to have not previously used nandrolone, nandrolone metabolites could be detected for up to 6 months in eight of 12 subjects (67%) for 19-NE and in 10 of 12 subjects (83%) for 19-NA.

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Science
Study
Date
1 May 2005
People
Bagchus, Wilma M.
De Jager-Van Der Veen, Suzanne M.
Geurts, T.B. Paul
Port, Andreas
Smeets, Jean M.W.
Verheul, Herman A.M.
Country
Netherlands
Language
English
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S1. Anabolic Agents
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19-norandrosterone
19-noretiocholanolone
Nandrolone
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Scientific article
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1 August 2019
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