Detection of testosterone doping in female athletes

Detection of testosterone doping in female athletes / David J. Handelsman, Stéphane Bermon. - (Drug Testing and Analysis (2019) 27 August).
- PMID: 31454165.
- DOI: 10.1002/dta.2689


Abstract

Testosterone doping remains a prevalent and potent form of drug cheating among elite athletes. In men, the urine testosterone (T) to epitestosterone (E) ratio (T/E ratio) can identify administration of exogenous T by its suppression of endogenous T production through strong negative feedback on endogenous T and E production as well as spill over into urine of extra testosterone. However, this mechanism may be partially inoperative in females whose much lower circulating T derives from three sources, none subject to powerful negative T feedback. Hence, additional methods to detect T doping in females are required. In this study we report two cases of elite female athletes who were sanctioned for T doping proven by measurement of serum T using liquid chromatography−mass spectrometry (LC–MS), when serial urine T and T/E ratio in one were not indicative of T doping, and in the other were nullified by incidental genetic inactivation of T glucuronidation through the uridine diphosphoglucuronosyl transferase 2B17 (UGT2B17) deletion genotype–phenotype. These findings indicate the potential for serum T measurement by LC–MS to detect T doping in female athletes, especially if implemented in the Bayesian format of an athlete biological passport.

Parameters

Science
Study
Date
27 August 2019
People
Bermon, Stéphane
Handelsman, David J.
Country
Australia
France
Language
English
Sport/IFs
Athletics (WA) - World Athletics
Other organisations
Laboratoire Motricité Humaine Expertise Sport Santé (LAMHESS)
Université Côte d'Azur - University of Côte d'Azur
Université internationale de Monaco - International University of Monaco (IUM)
University of Sydney (USyd)
Analytical aspects
Testing method development
Doping classes
S1. Anabolic Agents
Substances
T/E ratio (testosterone / epitestosterone)
Testosterone
Document category
Abstract
Date generated
9 September 2019
Date of last modification
11 September 2019
Category
  • Legal Source
  • Education
  • Science
  • Statistics
  • History
Country & language
  • Country
  • Language
Other filters
  • ADRV
  • Legal Terms
  • Sport/IFs
  • Other organisations
  • Laboratories
  • Analytical aspects
  • Doping classes
  • Substances
  • Medical terms
  • Various
  • Version
  • Document category
  • Document type
Publication period
Origin