Effects of Terbutaline Sulfate on Physiological and Biomechanical as Well as Perceived Exertion in Healthy Active Athletes: A Pilot Study

Effects of Terbutaline Sulfate on Physiological and Biomechanical as Well as Perceived Exertion in Healthy Active Athletes : A Pilot Study / Hanen Hafedh, Maamer Slimani, Bianca Miarka, Ramzi Bettayeb, Nicola Luigi Bragazzi. - (Journal of Human Kinetics (2019) 69 (18 October); p. 169-178).
- PMID: 31666899.
- PMCID: PMC6815083.
- DOI: 10.2478/hukin-2018-0097


This study aimed to investigate the effects of beta2-agonist terbutaline sulfate (TER) at a supra-therapeutic dose (8 mg) on aerobic exercise performance. Twelve (6 females and 6 males) amateur athletes familiarized with all experimental procedures had their anthropometric data obtained on day 1. On days 2 and 3 either 8 mg of TER or a placebo (PLA) was administered orally (double-blind manner) to participants who had rested for 3 h prior to aerobic exercise performance 20 m multistage fitness test (MSFT)]. This test was used to predict maximal oxygen uptake (VO2max) and velocity at which VO2max occurs (vVO2max). The Borg rating of perceived exertion (RPE), cardiovascular variables [heart rate (HR) and blood pressure (BP)] and blood glucose concentration [BGC] were obtained 15 min pre- and immediately post-MSFT. Significant mean group differences were reported between PLA and TER groups (p < 0.05), respectively, in the RPE (15.6 ± 1.2 vs. 17.3 ± 1.5 a.u.), maximum heart rate (HRmax: 191.2 ± 7.1 vs. 197.2 ± 8.6 bpm) and BGC (118.4 ± 18.3 vs. 141.2 ± 15.8 mg/dL) post-MSFT. The main effect of gender (male vs. female) in TER and PLA groups (p< 0.05) was observed, with higher estimated VO2max, vVO2max, HRmax and a lower mean HR pre-test in male than female athletes. For these reasons, the inclusion of TER in the Prohibited List should be re-discussed because of the lack of ergogenic effects.

Original document


18 October 2019
Bettayeb, Ramzi
Bragazzi, Nicola Luigi
Hafedh, Hanen
Miarka, Bianca
Slimani, Maamer
Other organisations
Universidade Federal de Juiz de Fora (UFJF) - Federal University of Juiz de Fora
Università di Genova (UniGe) - University of Genoa
University of Jendouba
Doping classes
S3. Beta-2 Agonists
Document category
Scientific article
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Pdf file
Date generated
23 October 2019
Date of last modification
15 November 2019
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