Effects of Terbutaline Sulfate on Physiological and Biomechanical as Well as Perceived Exertion in Healthy Active Athletes: A Pilot Study

Effects of Terbutaline Sulfate on Physiological and Biomechanical as Well as Perceived Exertion in Healthy Active Athletes : A Pilot Study / Hanen Hafedh, Maamer Slimani, Bianca Miarka, Ramzi Bettayeb, Nicola Luigi Bragazzi. - (Journal of Human Kinetics (2019) 69 (18 October); p. 169-178).
- PMID: 31666899.
- PMCID: PMC6815083.
- DOI: 10.2478/hukin-2018-0097


This study aimed to investigate the effects of beta2-agonist terbutaline sulfate (TER) at a supra-therapeutic dose (8 mg) on aerobic exercise performance. Twelve (6 females and 6 males) amateur athletes familiarized with all experimental procedures had their anthropometric data obtained on day 1. On days 2 and 3 either 8 mg of TER or a placebo (PLA) was administered orally (double-blind manner) to participants who had rested for 3 h prior to aerobic exercise performance 20 m multistage fitness test (MSFT)]. This test was used to predict maximal oxygen uptake (VO2max) and velocity at which VO2max occurs (vVO2max). The Borg rating of perceived exertion (RPE), cardiovascular variables [heart rate (HR) and blood pressure (BP)] and blood glucose concentration [BGC] were obtained 15 min pre- and immediately post-MSFT. Significant mean group differences were reported between PLA and TER groups (p < 0.05), respectively, in the RPE (15.6 ± 1.2 vs. 17.3 ± 1.5 a.u.), maximum heart rate (HRmax: 191.2 ± 7.1 vs. 197.2 ± 8.6 bpm) and BGC (118.4 ± 18.3 vs. 141.2 ± 15.8 mg/dL) post-MSFT. The main effect of gender (male vs. female) in TER and PLA groups (p< 0.05) was observed, with higher estimated VO2max, vVO2max, HRmax and a lower mean HR pre-test in male than female athletes. For these reasons, the inclusion of TER in the Prohibited List should be re-discussed because of the lack of ergogenic effects.

Original document


Research / Study
18 October 2019
Bettayeb, Ramzi
Bragazzi, Nicola Luigi
Hafedh, Hanen
Miarka, Bianca
Slimani, Maamer
Other organisations
Universidade Federal de Juiz de Fora (UFJF) - Federal University of Juiz de Fora
Università di Genova (UniGe) - University of Genoa
University of Jendouba
Doping classes
S3. Beta-2 Agonists
Document category
Scientific article
Document type
Pdf file
Date generated
23 October 2019
Date of last modification
15 November 2019
  • Legal Source
  • Education
  • Science
  • Statistics
  • History
Country & language
  • Country
  • Language
Other filters
  • ADRV
  • Legal Terms
  • Sport/IFs
  • Other organisations
  • Laboratories
  • Analytical aspects
  • Doping classes
  • Substances
  • Medical terms
  • Various
  • Version
  • Document category
  • Document type
Publication period