Hepatotoxicity associated with illicit use of anabolic androgenic steroids in doping

Hepatotoxicity associated with illicit use of anabolic androgenic steroids in doping / R. Solimini, M.C. Rotolo, L. Mastrobattista, C. Mortali, A. Minutillo, S. Pichini, R. Pacifici, I. Palmi. - (European Review for Medical and Pharmacological Sciences 21 (2017) 1 Suppl. (March); p. 7-16).
- PMID: 28379599


Anabolic Androgenic Steroids (AAS) abuse and misuse is nowadays a harmful habit involving both professional or recreational athletes, as well as general population. AAS are also frequently present in over-the-counter dietary supplements without being declared in the list of ingredients, leaving consumers unaware of the risks of adverse effects. Indeed, health risks of AAS consumption in pharmaceutical preparations or dietary complements seem still underestimated and under-reported. The variety of complications due to AAS misuse involves cardiovascular, central nervous, musculoskeletal and genitourinary systems of both males and females; psychiatric and behavioral effects, damages to metabolic system, skin and mainly liver. For instance, relevant concern has been raised by the AAS hepatotoxicity including adenoma, hepatocellular carcinoma, cholestasis, and peliosis hepatis. The present review reports the information available on the hepatotoxic effects of AAS use in professional and amateur athletes.

Original document


1 March 2017
Mastrobattista, L.
Minutillo, Adele
Mortali, C.
Pacifici, R.
Palmi, I.
Rotolo, M.C.
Solimini, R.
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Istituto Superiore di Sanità (ISS) - Italian National Institute of Health
Doping classes
S1. Anabolic Agents
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Health effects
Psychiatric disorders
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Scientific article
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Date generated
30 March 2020
Date of last modification
2 December 2021
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