Fluorescence Chemosensing of Meldonium Using a Cross-Reactive Sensor Array

Fluorescence Chemosensing of Meldonium Using a Cross-Reactive Sensor Array / Ergin Yalcin, Cem Erkmen, Tugba Taskin-Tok, Mehmet Gokhan Caglayan. - (Analyst (2020) 30 March).
- PMID: 32226998.
- DOI: 10.1039/d0an00209g


Abstract

In this paper, we report a fluorescent sensor array approach for the urinary detection of a prohibited substance in sports, meldonium. Four chemosensors with ethidium bromide scaffolds were employed in this method. The interaction between meldonium and chemosensors was investigated by different techniques, such as ultraviolet-visible absorption and fluorescence spectroscopy, nuclear magnetic resonance, and mass spectrometry. Molecular dynamics simulation was also used to elucidate and support the interaction mechanisms between meldonium and the chemosensors. Differential responses obtained from the sensor array enabled the qualitative and quantitative analyses of meldonium with low error values. This method was able to detect and quantify meldonium at the nM level, fulfilling the requirements of minimum performance defined by the World Anti-Doping Agency.

Parameters

Science
Study
Date
28 February 2020
People
Caglayan, Mehmet Gokhan
Erkmen, Cem
Taskin-Tok, Tugba
Yalsin, Ergin
Country
Turkey
Language
English
ADRV
Adverse Analytical Finding / presence
Other organisations
Ankara Üniversitesi - Ankara University
Gaziantep Üniversitesi - Gaziantep University
İskenderun Technical University (ISTEI) - Iskenderun Technical University
Analytical aspects
Testing method development
Doping classes
S4. Hormone And Metabolic Modulators
Substances
Meldonium
Document category
Abstract
Date generated
22 April 2020
Date of last modification
1 May 2020
Category
  • Legal Source
  • Education
  • Science
  • Statistics
  • History
Country & language
  • Country
  • Language
Other filters
  • ADRV
  • Legal Terms
  • Sport/IFs
  • Other organisations
  • Laboratories
  • Analytical aspects
  • Doping classes
  • Substances
  • Medical terms
  • Various
  • Version
  • Document category
  • Document type
Publication period
Origin