Octodrine: New Questions and Challenges in Sport Supplements

Octodrine : New Questions and Challenges in Sport Supplements / Valeria Catalani, Mariya Prilutskaya, Ahmed Al-Imam, Shanna Marrinan, Yasmine Elgharably, Mire Zloh, Giovanni Martinotti, Robert Chilcott, Ornella Corazza. - (Brain Sciences 8 (2018) 2 (February); p. 1-13)

  • PMID: 29461475
  • PMCID: PMC5836053
  • DOI: 10.3390/brainsci8020034


Background: Octodrine is the trade name for Dimethylhexylamine (DMHA), a central nervous stimulant that increases the uptake of dopamine and noradrenaline. Originally developed as a nasal decongestant in the 1950's, it has recently been re-introduced on the market as a pre-workout and 'fat-burner' product but its use remains unregulated. Our work provides the first observational cross-sectional analytic study on Octodrine as a new drug trend and its associated harms after a gap spanning seven decades.

Methods: A comprehensive multilingual assessment of literature, websites, drug fora and other online resources was carried out with no time restriction in English, German, Russian and Arabic. Keywords included Octodrine's synonyms and chemical isomers.

Results: Only five relevant publications emerged from the literature search, with most of the available data on body building websites and fora. Since 2015, Octodrine has been advertised online as "the next big thing" and "the god of stimulants," with captivating marketing strategies directed at athletes and a wider cohort of users. Reported side-effects include hypertension, dyspnoea and hyperthermia.

Conclusions: The uncontrolled use of Octodrine, its physiological and psychoactive effects raise serious health implications with possible impact on athletes and doping practices. This new phenomenon needs to be thoroughly studied and monitored.

Keywords: DMHA; ambredin; anti-obesity agents; dimethylhexylamine; fitness; novel psychoactive substance; octodrine; performance and image-enhancing drugs; weight loss.

Original document


1 June 2020
Al-Imam, Ahmed
Catalani, Valeria
Chilcott, Robert
Corazza, Ornella
Elgharably, Yasmine
Marrinan, Shanna
Martinotti, Giovanni
Prilutskaya, Mariya
Zlohm, Mire
United Kingdom
Other organisations
Semey State Medical Academy
Università degli Studi "Gabriele d'Annunzio" (Ud'A) - D'Annunzio University
University of Baghdad (UoB)
University of Hertfordshire (UOH)
Doping classes
S6. Stimulants
Octodrine (1,5-dimethylhexylamine)
Medical terms
Health effects
Mental disorders
Gym/fitness environment
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Pdf file
Date generated
16 June 2020
Date of last modification
2 December 2021
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