Implementation of the HIF activator IOX-2 in routine doping controls - Pilot study data

Implementation of the HIF activator IOX-2 in routine doping controls - Pilot study data / Christian Görgens, Sven Guddat, Christina Bosse, Andre Knoop, Hans Geyer, Mario Thevis. - (Drug Testing and Analysis (2020) 18 August)

  • PMID: 32809277
  • DOI: 10.1002/dta.2914

Abstract

Early in 2020, racehorse doping cases revolved around the hypoxia-inducible factor (HIF) activator IOX-2. While the composition of IOX-2 has also been known and monitored in human doping controls for several years, the testing capability of routine sports drug testing methods was revisited for this newly surfaced doping agent. IOX-2 and the analytically well-established HIF activator roxadustat (FG-4592) share identical precursor/product ion pairs, enabling their co-detection in existing initial testing procedures in routine doping controls for the intact unconjugated analytes. In addition, hydroxylated IOX-2 and the corresponding glucuronic acid conjugates were identified as major metabolites in a microdose elimination study, contributing to enhanced initial testing and confirmation procedures.

Original document

Parameters

Science
Study
Date
17 August 2020
People
Bosse, Christina
Geyer, Hans
Görgens, Christian
Guddat, Sven
Knoop, Andre
Thevis, Mario
Country
Germany
Language
English
Other organisations
Deutsche Sporthochschule Köln (DSHS) - German Sport University Cologne
European Monitoring Center for Emerging Doping Agents (EuMoCEDA)
Analytical aspects
Mass spectrometry analysis
Testing method development
Doping classes
S2. Peptide Hormones, Growth Factors
Substances
Roxadustat (FG-4592)
Medical terms
Health effects
Document category
Scientific article
Document type
Pdf file
Date generated
7 September 2020
Date of last modification
13 September 2020
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  • Legal Source
  • Education
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  • ADRV
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  • Sport/IFs
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  • Analytical aspects
  • Doping classes
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  • Various
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