Glycine-modified growth hormone secretagogues identified in seized doping material

Glycine-modified growth hormone secretagogues identified in seized doping material / Paulina Marta Gajda, Niels Bjerre Holm, Lars Jakobsen Hoej, Brian Schou Rasmussen, Petur Weihe Dalsgaard, Lotte Ask Reitzel, Kristian Linnet. - (Drug Testing and Analysis 11 (2019) 2 (February); p. 350-354)

  • PMID: 30136411
  • DOI: 10.1002/dta.2489

Abstract

A number of unknown pharmaceutical preparations seized by Danish customs authorities were submitted for liquid chromatography-high resolution mass spectrometry (LC-HRMS) analysis. Comparison with reference standards unequivocally identified the content of the powders as analogs of the growth hormone secretagogues GHRP-2 (Pralmorelin), GHRP-6, Ipamorelin, and modified growth hormone releasing factor (modified GRF 1-29), which can be used as performance-enhancing substances in sports. In all cases, the detected modification involved the addition of an extra glycine amino acid at the N-terminus, and analytical methods targeting growth hormone secretagogues should hence be updated accordingly.

Parameters

Science
Study
Date
22 August 2018
People
Dalsgaard, Petur, Weihe
Gajda, Paulina Marta
Hoej, Lars Jakobsen
Holm, Niels Bjerre
Linnet, Kristian
Rasmussen, Brian Schou
Reitzel, Lotte Ask
Country
Denmark
Language
English
Other organisations
Københavns Universitet - University of Copenhagen (UCPH)
Analytical aspects
Mass spectrometry analysis
Testing method development
Doping classes
S2. Peptide Hormones, Growth Factors
Substances
Growth hormone (GH)
Growth Hormone Releasing Peptide (GHRP)
Pralmorelin (GHRP-2)
Various
Illegal production / trade
Document category
Abstract
Date generated
23 September 2020
Date of last modification
24 September 2020
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  • Legal Source
  • Education
  • Science
  • Statistics
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  • ADRV
  • Legal Terms
  • Sport/IFs
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  • Laboratories
  • Analytical aspects
  • Doping classes
  • Substances
  • Medical terms
  • Various
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Origin