Gene doping and genomic science in sports: where are we?

Gene doping and genomic science in sports : where are we? Sheila López, João Meirelles, Vanessa Rayol, Gabriella Poralla, Nicole Woldmar, Bruna Fadel, Mariana Figueiredo, Mônica da Costa Padilha, Francisco Radler de Aquino Neto, Henrique Marcelo Gualberto Pereira, Luciana Pizzatti. - (Bioanalysis 12 (2020) 11 (19 June); p. 801-811)

  • PMID: 32558587
  • DOI: 10.4155/bio-2020-0093


The misuse of sport-related gene transfer methods in elite athletes is a real and growing concern. The success of gene therapy in the treatment of hereditary diseases has been most evident since targets in gene therapy products can be used in healthy individuals to improve sports performance. Performing these practices threatens the sporting character of competitions and may pose potential health hazards. Since the World Anti-Doping Agency pronouncement on the prohibition of such practices in 2003, several researchers have been trying to address the challenge of developing an effective method for the detection of genetic doping. This review presents an overview of the published methods developed for this purpose, the advantages and limitations of technologies and the putative target genes. At last, we present the perspective related to the application of the detection methods in the doping control field.


19 June 2020
Fadel, Bruna
Figueiredo, Mariana
López, Sheila
Meirelles, João
Neto, Francisco Radler Aquino
Padilha, Mônica Costa
Pereira, Henrique Marcelo Gualberto
Pizzatti, Luciana
Poralla, Gabriella
Rayol, Vanessa
Woldmar, Nicole
Rio de Janeiro, Brazil: Laboratório Brasileiro de Controle de Dopagem – LBCD – LADETEC / IQ - UFRJ
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M3. Gene And Cell Doping
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Gene Therapy
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Date generated
28 September 2020
Date of last modification
1 October 2020
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