The effect of nandrolone decanoate on bone mineral density, muscle mass, and hemoglobin levels in elderly women with osteoporosis

The effect of nandrolone decanoate on bone mineral density, muscle mass, and hemoglobin levels in elderly women with osteoporosis : a double-blind, randomized, placebo-controlled clinical trial /  Alberto Frisoli Jr, Paulo H.M. Chaves, Marcelo Medeiros Pinheiro, Vera Lucia Szejnfeld. - (Journal of Gerontlolgy 60 (2005) 5 (May); p. 648-653)

  • PMID: 15972619
  • DOI: 10.1093/gerona/60.5.648


Methods: In a randomized, double-blind, placebo-controlled clinical trial, we evaluated the effect of a 2-year treatment with nandrolone decanoate (ND) on bone mineral density (BMD) of lumbar spine, femoral neck, and trochanter and on vertebral fracture rate, muscle mass, and hemoglobin levels. Sixty-five osteoporotic women older than 70 years were studied. Thirty-two patients received injections of 50 mg ND, and 33 received placebos every 3 weeks. All patients received 500 mg calcium tablets daily.

Results: Compared to baseline, ND increased the BMD of the lumbar spine (3.4% +/- 6.0 and 3.7% +/- 7.4; p < .05) and femoral neck (4.1% +/- 7.3 and 4.7% +/- 8.0; p < .05) after 1 and 2 years, respectively. The BMD of trochanter increased significantly only after the first year (4.8% +/- 9.3, p < .05). Compared to the placebo group, the ND group presented with significantly increased BMD of the trochanter and neck. ND significantly reduced incidence of new vertebral fractures (21% vs 43% in the placebo group; p < .05). ND showed a significant statistical increase in lean body mass after the first (6.2% +/- 5.8; p < .01) and second years (11.9% +/- 29.2; p < .01). In addition, a 2-year treatment with ND significantly increased hemoglobin levels compared to baseline (14.3%; p < .01) and placebo (p < .01).

Conclusions: ND increased BMD, hemoglobin levels, and muscle mass, and reduced the vertebral fracture rate of elderly osteoporotic women.

Original document


Research / Study
1 May 2005
Chaves, Paulo H.M.
Frisoli Jr, Alberto
Pinheiro, Marcelo Medeiros
Szejnfeld, Vera Lucia
United States of America
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Johns Hopkins University
Universidade Federal de São Paulo (UNIFESP) - Federal University of São Paulo
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S1. Anabolic Agents
Nandrolone (19-nortestosterone)
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Long term effects
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Scientific article
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Date generated
22 October 2020
Date of last modification
27 October 2020
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