Doping control of testosterone and human chorionic gonadotrophin: a case study

Doping control of testosterone and human chorionic gonadotrophin : a case study / Douwe de Boer, E.G. de Jong, J.M. van Rossum, R.A. Maes. - (International Journal of Sports Medicine 12 (1991) 1 (February); p. 46-51)

  • PMID: 2030059
  • DOI: 10.1055/s-2007-1024654

Erratum in:

  • Int J Sports Med 1991 Aug;12(4):430. De Jong EG [corrected to de Jong EG]


Doping control for testosterone and human Chorionic Gonadotrophin (hCG) requires special attention as a difference must be made between the endogenous and exogenous origin of both substances. The detection of exogenous testosterone is based on the ratio of testosterone- to epitestosterone-glucuronide (T/E) in urine. The problems with this ratio are discussed. For hCG analysis in urine the utilization of sandwich-type hCG specific assays instead of hCG/hCG beta competitive assays is recommended. A case study in which an athlete self-administered testosterone and hCG before a competition is described. The T/E ratio and hCG concentration in urine were followed during this period of self-administration. The results demonstrate the relevance of the T/E ratio and of the selected hCG assay. The ratio of testosterone to human Luteinizing Hormone (T/hLH) in serum also indicated the use of hormones. Although the athlete's urine was negative for exogenous testosterone directly after competition, he would have been found positive for hCG.


Case report
1 February 1991
Boer, Douwe de
Jong, Edward G. de
Maes, Robert A.A.
Rossum, J.M. van
Adverse Analytical Finding / presence
Other organisations
Nederlands Instituut voor Drugs- en Doping Research (NIDDR) - Netherlands Institute for Drugs and Doping Research
Doping classes
S1. Anabolic Agents
S2. Peptide Hormones, Growth Factors
Human chorionic gonadotrophin (hCG)
T/E ratio (testosterone / epitestosterone)
Doping control
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Date generated
19 November 2020
Date of last modification
21 November 2020
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