Excretion of 19-norandrosterone after consumption of boar meat

Excretion of 19-norandrosterone after consumption of boar meat / Frank Hülsemann, Gregor Fußhöller, Christine Lehn, Mario Thevis. - (Drug Testing and Analysis (2020) Special Issue (30 October); p. 1-7)

  • PMID: 33125835
  • DOI: 10.1002/dta.2958


Abstract

The consumption of the offal of noncastrated pigs can lead to the excretion of 19-norandrosterone (NorA) in urine of humans. In doping control, GC/C/IRMS is the method of choice to differentiate between an endogenous or exogenous origin of urinary NorA. In some cases, after the consumption of wild boar offal, the δ13 C values of urinary NorA fulfill the criteria of an adverse analytical finding due to differing food sources of boar and consumer. However, consumption of wild boar's offal is not very common in Germany, and thus, the occurrence of such an analytical finding is unlikely. In contrast, the commerce with wild boar meat has increased in Germany within the last years. Up to 20,000 tons of wild boar meat are annually consumed. In order to probe for the probability of the occurrence of urinary NorA after consumption of wild boar meat, human urine samples were tested following the ingestion of commercially available game. In approximately half of the urine samples, traces of NorA were detected postadministration of 200 to 400 g boar meat. The highest urinary concentration was 2.9 ng/ml, and significant amounts were detected up to 9 h after the meal. δ13 C values ranged from -18.5‰ to -23.5‰, which would have led to at least two adverse analytical findings if the samples were collected in an antidoping context. IRMS analysis on German boar tissue samples showed that δ13 C values for wild boar's steroids are unpredictable and may vary seasonally.

Original document

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Science
Study
Date
30 October 2020
People
Fußhöller, Gregor
Hülsemann, Frank
Lehn, Christine
Thevis, Mario
Country
Germany
Language
English
Other organisations
Deutsche Sporthochschule Köln (DSHS) - German Sport University Cologne
Ludwig-Maximilians-Universität München (LMU) - Ludwig Maximilian University of Munich
Analytical aspects
Mass spectrometry analysis
Doping classes
S1. Anabolic Agents
Substances
19-norandrosterone
Nandrolone
Various
Meat contamination
Document category
Scientific article
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Pdf file
Date generated
2 December 2020
Date of last modification
8 December 2020
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