Selective androgen receptor modulators for the treatment of late onset male hypogonadism

Selective androgen receptor modulators for the treatment of late onset male hypogonadism / Christopher C. Coss, Amanda Jones, Michael L. Hancock, Mitchell S. Steiner, James T. Dalton. - (Asian Journal of Andrology 16 (2014) 2 (March-April); p. 256-261)

  • PMID: 24407183
  • PMCID: PMC3955335
  • DOI: 10.4103/1008-682X.122339


Several testosterone preparations are used in the treatment of hypogonadism in the ageing male. These therapies differ in their convenience, flexibility, regional availability and expense but share their pharmacokinetic basis of approval and dearth of long-term safety data. The brevity and relatively reduced cost of pharmacokinetic based registration trials provides little commercial incentive to develop improved novel therapies for the treatment of late onset male hypogonadism. Selective androgen receptor modulators (SARMs) have been shown to provide anabolic benefit in the absence of androgenic effects on prostate, hair and skin. Current clinical development for SARMs is focused on acute muscle wasting conditions with defined clinical endpoints of physical function and lean body mass. Similar regulatory clarity concerning clinical deficits in men with hypogonadism is required before the beneficial pharmacology and desirable pharmacokinetics of SARMs can be employed in the treatment of late onset male hypogonadism.

Original document


19 December 2013
Coss, Christopher C.
Dalton, James T.
Hancock, Michael L.
Jones, Amanda
Steiner, Mitchell S.
United States of America
Doping classes
S1. Anabolic Agents
Selective androgen receptor modulators (SARMs)
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Legitimate Medical Treatment
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Pdf file
Date generated
14 January 2021
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