Dried blood spots for anti-doping : Why just going volumetric may not be sufficient / Marc Luginbühl , Stefan Gaugler. - (Drug Testing and Analysis 13 (2021) 1 (January); p. 69-73)
- PMID: 33201591
- DOI: 10.1002/dta.2977
The perspective discusses quantitative DBS analysis for anti-doping testing in an athletic population and why only using volumetric sampling for this subgroup might not be enough. It presents examples to highlight where HCT variations occur, followed by a whole blood to plasma ratio and an HCT extraction bias discussion. Finally, options to correct for the HCT bias are presented.