Selective androgen receptor modulators in preclinical and clinical development

Selective androgen receptor modulators in preclinical and clinical development / Ramesh Narayanan, Michael L. Mohler, Casey E. Bohl, Duane D. Miller, James T. Dalton. - (Nuclear Receptor Signaling (2008) 26 November; p. 1-26)

  • PMID: 19079612
  • PMCID: PMC2602589
  • DOI: 10.1621/nrs.06010


Androgen receptor (AR) plays a critical role in the function of several organs including primary and accessory sexual organs, skeletal muscle, and bone, making it a desirable therapeutic target. Selective androgen receptor modulators (SARMs) bind to the AR and demonstrate osteo- and myo-anabolic activity; however, unlike testosterone and other anabolic steroids, these nonsteroidal agents produce less of a growth effect on prostate and other secondary sexual organs. SARMs provide therapeutic opportunities in a variety of diseases, including muscle wasting associated with burns, cancer, or end-stage renal disease, osteoporosis, frailty, and hypogonadism. This review summarizes the current standing of research and development of SARMs, crystallography of AR with SARMs, plausible mechanisms for their action and the potential therapeutic indications for this emerging class of drugs.

Original document


26 November 2008
Bohl, Casey E.
Dalton, James T.
Miller, Duane D.
Mohler, Michael L.
Narayanan, Ramesh
United States of America
Doping classes
S1. Anabolic Agents
Selective androgen receptor modulators (SARMs)
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Legitimate Medical Treatment
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Scientific article
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Date generated
28 January 2021
Date of last modification
3 February 2021
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