Urinary marker of oral pregnenolone administration

Urinary marker of oral pregnenolone administration / Christophe Saudan, Aurélien Desmarchelier, Pierre-Edouard Sottas, Patrice Mangin, Martial Saugy. - (Steroids 70 (2005) 3 (March); p. 179-183)

  • PMID: 15763596
  • DOI: 10.1016/j.steroids.2004.12.007


Pregnenolone (PREG) can potentially be abused by athletes to maintain an equilibration of the steroidal environment after sex steroids administrations. Five men volunteers orally ingested 50 mg PREG to determine optimal urinary markers for detection of this steroid. Our findings show that ingestion of PREG has no significant effects on the testosterone/epitestosterone (T/E) and testosterone/luteinizing hormone (T/LH) ratios, whereas variable changes on the carbon isotopic values of three T metabolites: androsterone, etiocholanolone, 5beta-androstane-3alpha,17beta-diol (5beta-androstanediol) together with 16(5alpha)-androsten-3alpha-ol (androstenol) and 5beta-pregnane-3alpha,20alpha-diol (pregnanediol) have been observed. The difference between the carbon isotopic values (delta13C-values) of androstenol and pregnanediol is potentially the most reliable marker of exogenous PREG administration in males. For all subjects, the differences differ by 3.0 per thousand or more over a period of about 10 h and for both of them the detection window for positivity is extended over 40 h.

Original document


Research / Study
1 March 2021
Desmarchelier, Aurélien
Mangin, Patrice
Saudan, Christophe
Saugy, Martial
Sottas, Pierre-Edouard
Lausanne, Switzerland: Laboratoire Suisse d’Analyse du Dopage
Document category
Scientific article
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Pdf file
Date generated
10 March 2021
Date of last modification
12 March 2021
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