SARM-S4 and metabolites detection in sports drug testing: a case report

SARM-S4 and metabolites detection in sports drug testing: a case report / Elia Grata, Laurent Perrenoud, Martial Saugy, Norbert Baume. - (Forensic Science International 213 (2011) 1-3 (10 December); p. 104-108)

  • PMID: 21816554
  • DOI: 10.1016/j.forsciint.2011.07.014


Recently, pharmaceutical industry developed a new class of therapeutics called Selective Androgen Receptor Modulator (SARM) to substitute the synthetic anabolic drugs used in medical treatments. Since the beginning of the anti-doping testing in sports in the 1970s, steroids have been the most frequently detected drugs mainly used for their anabolic properties. The major advantage of SARMs is the reduced androgenic activities which are the main source of side effects following anabolic agents' administration. In 2010, the Swiss laboratory for doping analyses reported the first case of SARMs abuse during in-competition testing. The analytical steps leading to this finding are described in this paper. Screening and confirmation results were obtained based on liquid chromatography tandem mass spectrometry (LC-MS/MS) analyses. Additional information regarding the SARM S-4 metabolism was investigated by ultra high-pressure liquid chromatography coupled to quadrupole time-of-flight mass spectrometer (UHPLC-QTOF-MS).

Original document


Case report
3 August 2011
Baume, Norbert
Grata, Elia
Perrenoud, Laurent
Saugy, Martial
Other organisations
Centre Hospitalier Universitaire Vaudois (CHUV) - Lausanne University Hospital
Université de Genève - University of Geneva
Université de Lausanne (UNIL) - University of Lausanne
Lausanne, Switzerland: Laboratoire Suisse d’Analyse du Dopage
Analytical aspects
Mass spectrometry analysis
Testing method development
Doping classes
S1. Anabolic Agents
Selective androgen receptor modulators (SARMs)
Document type
Pdf file
Date generated
23 August 2021
Date of last modification
26 August 2021
  • Legal Source
  • Education
  • Science
  • Statistics
  • History
Country & language
  • Country
  • Language
Other filters
  • ADRV
  • Legal Terms
  • Sport/IFs
  • Other organisations
  • Laboratories
  • Analytical aspects
  • Doping classes
  • Substances
  • Medical terms
  • Various
  • Version
  • Document category
  • Document type
Publication period