Meldonium residues in milk: A possible scenario for inadvertent doping in sports?

Meldonium residues in milk : A possible scenario for inadvertent doping in sports? / Sven Guddat, Christian Görgens, Tim Sobolevsky, Mario Thevis. - (Drug Testing and Analysis (2021) 26 August)

  • PMID: 34448364
  • DOI: 10.1002/dta.3145


Abstract

Lately, the veterinary drug Emidonol® has been discussed as a possible scenario for inadvertent doping in sports. Emidonol® is approved for use in livestock breeding, exhibiting antihypoxic and weak sedative effects. The veterinary drug rapidly dissociates into meldonium, a substance prohibited in sports, and is excreted largely in its unchanged form into urine. To investigate if residues of meldonium in edible produce may result in adverse analytical findings in sports drug testing, a pilot study was conducted with three volunteers consuming a single dose of 100 ml meldonium-spiked milk at a concentration of 500 ng/ml (Study 1), and multiple doses of 100 ml of meldonium-spiked milk (500 ng/ml) on five consecutive days (Study 2). In the single dose study, urinary meldonium concentrations peaked between 2 and 6 h post-administration with maximum values of 7.5 ng/ml, whereas maximum meldonium concentrations of 18.6 ng/ml were determined after multiple doses 4 h post-administration. All samples were analyzed using an established and validated protocol based on HILIC-HRMS/MS.

Original document

Parameters

Science
Study
Date
10 August 2021
People
Görgens, Christian
Guddat, Sven
Sobolevsky, Tim
Thevis, Mario
Country
Germany
Language
English
Other organisations
Deutsche Sporthochschule Köln (DSHS) - German Sport University Cologne
Laboratories
Los Angeles, USA: UCLA Olympic Analytical Laboratory
Analytical aspects
Mass spectrometry analysis
Doping classes
S4. Hormone And Metabolic Modulators
Substances
Meldonium
Various
Contamination
Food and/or drinks
Document category
Scientific article
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Pdf file
Date generated
30 August 2021
Date of last modification
1 September 2021
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  • Legal Source
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