Enclomiphene citrate stimulates testosterone production while preventing oligospermia : a randomized phase II clinical trial comparing topical testosterone / Ronald D. Wiehle, Gregory K. Fontenot, Jenny Wike, Kuang Hsu, Jennifer Nydell, Larry Lipshultz
- Fertility and Sterility 102 (2014) 3 (September), p. 720-727
- PMID: 25044085
- DOI: 10.1016/j.fertnstert.2014.06.004
Objective: To determine the effect of enclomiphene citrate in men with secondary hypogonadism.
Design: Phase II clinical trial.
Setting: Community dwelling men making visits to physician offices.
Patient(s): Men with secondary hypogonadism.
Intervention(s): Oral administration of enclomiphene citrate or 1% topical T gel.
Main outcome measure(s): Luteinizing hormone, FSH, T, and semen analysis.
Result(s): Treatment with enclomiphene citrate resulted in increased morning serum T, E2, and LH levels similar to those obtained with a topical T gel in men with secondary hypogonadism. Follicle-stimulating hormone and LH were increased with enclomiphene, and sperm counts were conserved.
Conclusion(s): Enclomiphene citrate reverses the two hallmarks of secondary hypogonadism, namely, low serum total T and low or inappropriately normal LH while preserving sperm production.