Cocaine and benzoylecgonine excretion in humans

Cocaine and benzoylecgonine excretion in humans / H.E. Hamilton, J.E. Wallace, E.L. Shimek Jr, P. Land, S.C. Harris, J.G. Christenson

  • Journal of forensic sciences 22 (1977) 4 (October), p. 697-707
  • PMID: 370332University of Texas System (UT System)


Maximal urinary excretion of unchanged cocaine occurred within 2 h of the intranasal absorption of 1.5 mg/kg body weight of cocaine hydrochloride, and diminished rapidly thereafter. Excretion of benzoylecgonine was maximal 4 to 8 h following administration of the drug and diminished slowly over an interval of several days. Peak cocaine and benzoylecgonine concentrations observed were 24 and 75 microgram/ml, respectively. Benzoylecgonine/cocaine ratios were too varied to allow estimation of cocaine concentrations from benzoylecgonine concentration data or vice versa. Benzoylecgonine concentrations generally exceeded the corresponding cocaine values by a wide margin, but excretion of free cocaine in the absence of benzoylecgonine was observed in one subject. Cocaine was generally detected for only approximately 8 h, and for a maximum of 12 h, whereas benzoylecgonine was generally detected by chromatographic or enzyme immunologic assays for 48 to 72 h. Benzoylecgonine was positively identified in urine by raidoimmunoassay for 96 to 144 h after dosing.


Research / Study
1 October 1977
Christenson, J.G.
Hamilton, H.E.
Harris, S.C.
Land, P.
Shimek Jr., E.L.
Wallace, J.E.
United States of America
Other organisations
University of Texas System (UT System)
Analytical aspects
Half-life / excretion time of substance
Doping classes
S6. Stimulants
Document category
Document type
Date generated
2 May 2024
Date of last modification
6 May 2024
  • Legal Source
  • Education
  • Science
  • Statistics
  • History
Country & language
  • Country
  • Language
Other filters
  • ADRV
  • Legal Terms
  • Sport/IFs
  • Other organisations
  • Laboratories
  • Analytical aspects
  • Doping classes
  • Substances
  • Medical terms
  • Various
  • Version
  • Document category
  • Document type
Publication period